HSPA6

HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) is a Protein Coding gene. Among its related pathways are Innate Immune System and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and heat shock protein binding. An important paralog of this gene is HSPA1B.

Heat Shock Protein Family A (Hsp70) Member 6

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).

Cellular response to heat Source: UniProtKB
Cellular response to unfolded protein Source: GO_Central
Chaperone cofactor-dependent protein refolding Source: GO_Central
Protein refolding Source: UniProtKB
Response to unfolded protein Source: ProtInc
Vesicle-mediated transport Source: GO_Central

Centriole; Cytosol; Blood microparticle; Extracellular exosome; Extracellular region; Nucleus; Plasma membrane; Cytoplasm