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Mouse Anti-HSPA6 Recombinant Antibody (CBFYH-2284) (CBMAB-H3297-FY)

This product is mouse antibody that recognizes HSPA6. The antibody CBFYH-2284 can be used for immunoassay techniques such as: IF, WB.
See all HSPA6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2284
Antibody Isotype
IgG2a
Application
IF, WB

Basic Information

Immunogen
Full length human recombinant protein of human HSPA6 produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Heat Shock Protein Family A (Hsp70) Member 6
Introduction
HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) is a Protein Coding gene. Among its related pathways are Innate Immune System and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and heat shock protein binding. An important paralog of this gene is HSPA1B.
Entrez Gene ID
UniProt ID
Alternative Names
Heat Shock Protein Family A (Hsp70) Member 6; Heat Shock 70kDa Protein 6 (HSP70B); Heat Shock 70kD Protein 6 (HSP70B); Heat Shock 70 KDa Protein B; HSP70B; Heat Shock 70 KDa Protein 6
Function
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).
Biological Process
Cellular response to heat Source: UniProtKB
Cellular response to unfolded protein Source: GO_Central
Chaperone cofactor-dependent protein refolding Source: GO_Central
Protein refolding Source: UniProtKB
Response to unfolded protein Source: ProtInc
Vesicle-mediated transport Source: GO_Central
Cellular Location
Centriole; Cytosol; Blood microparticle; Extracellular exosome; Extracellular region; Nucleus; Plasma membrane; Cytoplasm

Song, B., Shen, S., Fu, S., & Fu, J. (2022). HSPA6 and its role in cancers and other diseases. Molecular Biology Reports, 49(11), 10565-10577.

Zhou, X., Ji, Q., Li, Q., Wang, P., Hu, G., Xiao, F., ... & Guo, H. (2022). HSPA6 is correlated with the malignant progression and immune microenvironment of gliomas. Frontiers in Cell and Developmental Biology, 10, 833938.

Fu, Y., Lv, Z., Kong, D., Fan, Y., & Dong, B. (2022). High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Cell Proliferation, 55(7), e13257.

Shen, S., Wei, C., & Fu, J. (2021). RNA-sequencing reveals heat shock 70-kDa protein 6 (HSPA6) as a novel thymoquinone-upregulated gene that inhibits growth, migration, and invasion of triple-negative breast cancer cells. Frontiers in Oncology, 11, 667995.

Liu, S. Y., Yuan, D., Sun, R. J., Zhu, J. J., & Shan, N. N. (2021). Significant reductions in apoptosis-related proteins (HSPA6, HSPA8, ITGB3, YWHAH, and PRDX6) are involved in immune thrombocytopenia. Journal of Thrombosis and Thrombolysis, 51, 905-914.

Fa, J., Zhang, X., Zhang, X., Qi, M., Zhang, X., Fu, Q., ... & Wang, B. (2021). Long noncoding RNA lnc-TSSK2-8 activates canonical Wnt/β-Catenin signaling through small heat shock proteins HSPA6 and CRYAB. Frontiers in Cell and Developmental Biology, 9, 660576.

Wang, L., Hou, J., Wang, J., Zhu, Z., Zhang, W., Zhang, X., ... & Wang, X. (2020). Regulatory roles of HSPA6 in Actinidia chinensis Planch. root extract (acRoots)‐inhibited lung cancer proliferation. Clinical and Translational Medicine, 10(2), e46.

Kause, F., Zhang, R., Ludwig, M., Schmiedeke, E., Rissmann, A., Thiele, H., ... & Reutter, H. (2019). HSPA6: a new autosomal recessive candidate gene for the VATER/VACTERL malformation spectrum. Birth defects research, 111(10), 591-597.

Baena, M. M., Tizioto, P. C., Meirelles, S. L. C., & Regitano, L. C. D. A. (2018). HSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle. Revista Brasileira de Zootecnia, 47.

Deane, C. A., & Brown, I. R. (2018). Knockdown of heat shock proteins HSPA6 (Hsp70B’) and HSPA1A (Hsp70-1) sensitizes differentiated human neuronal cells to cellular stress. Neurochemical Research, 43, 340-350.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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