HTR2B

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

5-Hydroxytryptamine Receptor 2B

Activation of phospholipase C activity Source: UniProtKB
Behavior Source: UniProtKB-KW
Calcium-mediated signaling Source: UniProtKB
Cardiac muscle hypertrophy Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
Cellular response to temperature stimulus Source: UniProtKB
cGMP-mediated signaling Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Embryonic morphogenesis Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
G protein-coupled receptor internalization Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
Heart morphogenesis Source: UniProtKB
Intestine smooth muscle contraction Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of autophagy Source: UniProtKB
Negative regulation of cell death Source: UniProtKB
Neural crest cell differentiation Source: UniProtKB
Neural crest cell migration Source: UniProtKB
Phosphatidylinositol 3-kinase signaling Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating serotonin receptor signaling pathway Source: UniProtKB
Phosphorylation Source: UniProtKB
Positive regulation of cell division Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of nitric-oxide synthase activity Source: UniProtKB
Positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Protein kinase C signaling Source: UniProtKB
Regulation of behavior Source: UniProtKB
Release of sequestered calcium ion into cytosol Source: UniProtKB
Response to xenobiotic stimulus Source: UniProtKB
Vasoconstriction Source: UniProtKB

Cell membrane; Synaptosome

Extracellular: 1-56
Helical: 57-79
Cytoplasmic: 80-90
Helical: 91-113
Extracellular: 114-129
Helical: 130-151
Cytoplasmic: 152-171
Helical: 172-192
Extracellular: 193-216
Helical: 217-239
Cytoplasmic: 240-324
Helical: 325-345
Extracellular: 346-360
Helical: 361-382
Cytoplasmic: 383-481