IGFBP3

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Insulin Like Growth Factor Binding Protein 3

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253).

Promotes testicular germ cell apoptosis (PubMed:19952275).

Apoptotic process Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: MGI
Negative regulation of protein phosphorylation Source: MGI
Negative regulation of signal transduction Source: UniProtKB
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of myoblast differentiation Source: UniProtKB
Protein phosphorylation Source: MGI
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central

Secreted

Phosphorylated by FAM20C in the extracellular medium.