Mouse Anti-IGFBP3 Recombinant Antibody (2G6) (CBMAB-A4299-LY)

Name: Mouse Anti-IGFBP3 Recombinant Antibody (2G6)
SKU: CBMAB-A4299-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G6

Application

WB, ELISA

Immunogen

IGFBP3 (NP_000589.1, 182 a.a. ~ 291 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Insulin Like Growth Factor Binding Protein 3

Introduction

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Entrez Gene ID

3486

UniProt ID

P17936

Alternative Names

BP-53; IBP3

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253).

Promotes testicular germ cell apoptosis (PubMed:19952275).

Biological Process

Apoptotic process Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: MGI
Negative regulation of protein phosphorylation Source: MGI
Negative regulation of signal transduction Source: UniProtKB
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of myoblast differentiation Source: UniProtKB
Protein phosphorylation Source: MGI
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central

Cellular Location

Secreted

PTM

Phosphorylated by FAM20C in the extracellular medium.

Xiao, Z., Xie, Y., Huang, F., Yang, J., Liu, X., Lin, X., ... & Zheng, S. (2022). MicroRNA-205-5p plays a suppressive role in the high-fat diet-induced atrial fibrosis through regulation of the EHMT2/IGFBP3 axis. Genes & Nutrition, 17(1), 1-17.

Yang, J., He, Q., Wang, Y., Pan, Z., Zhang, G., Liang, J., ... & Chen, P. (2022). Gegen Qinlian Decoction ameliorates type 2 diabetes osteoporosis via IGFBP3/MAPK/NFATc1 signaling pathway based on cytokine antibody array. Phytomedicine, 94, 153810.

Almalki, A., Thomas, J. T., Khan, A. R. A., Almulhim, B., Alassaf, A., Alghamdi, S. A., ... & Alotaibi, S. (2022). Correlation between Salivary Levels of IGF-1, IGFBP-3, IGF-1/IGFBP3 Ratio with Skeletal Maturity Using Hand-Wrist Radiographs. International Journal of Environmental Research and Public Health, 19(6), 3723.

D’Addio, F., Maestroni, A., Assi, E., Ben Nasr, M., Amabile, G., Usuelli, V., ... & Fiorina, P. (2022). The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Nature communications, 13(1), 684.

Jin, L., Shen, F., Weinfeld, M., & Sergi, C. (2020). Insulin growth factor binding protein 7 (IGFBP7)-related cancer and IGFBP3 and IGFBP7 crosstalk. Frontiers in Oncology, 10, 727.

Long, Z., Gong, F., Li, Y., Fan, Z., & Li, J. (2020). Circ_0000285 regulates proliferation, migration, invasion and apoptosis of osteosarcoma by miR-409-3p/IGFBP3 axis. Cancer cell international, 20, 1-11.

Li, C. L., Liu, B., Wang, Z. Y., Xie, F., Qiao, W., Cheng, J., ... & Liu, D. S. (2020). Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3. Journal of molecular and cellular cardiology, 139, 98-112.

Yin, L., Chen, J., Ma, C., Pei, S., Du, M., Zhang, Y., ... & Feng, J. (2020). Hsa_circ_0046263 functions as a ceRNA to promote nasopharyngeal carcinoma progression by upregulating IGFBP3. Cell Death & Disease, 11(7), 562.

Xiong, L. L., Xue, L. L., Du, R. L., Zhou, H. L., Tan, Y. X., Ma, Z., ... & Wang, T. H. (2020). Vi4-miR-185-5p-Igfbp3 network protects the brain from neonatal hypoxic ischemic injury via promoting neuron survival and suppressing the cell apoptosis. Frontiers in Cell and Developmental Biology, 8, 529544.

Chen, C. H., Chen, P. Y., Lin, Y. Y., Feng, L. Y., Chen, S. H., Chen, C. Y., ... & Wei, K. C. (2019). Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. Journal of Neurosurgery, 132(1), 168-179.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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