Sign in or Register   Sign in or Register
  |  

Mouse Anti-IGFBP3 Recombinant Antibody (2G6) (CBMAB-A4299-LY)

The product is antibody recognizes IGFBP3. The antibody 2G6 immunoassay techniques such as: WB, ELISA.
See all IGFBP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IGFBP3 (NP_000589.1, 182 a.a. ~ 291 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Insulin Like Growth Factor Binding Protein 3
Introduction
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Entrez Gene ID
3486
UniProt ID
P17936
Alternative Names
BP-53; IBP3
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253).

Promotes testicular germ cell apoptosis (PubMed:19952275).
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: MGI
Negative regulation of protein phosphorylation Source: MGI
Negative regulation of signal transduction Source: UniProtKB
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of myoblast differentiation Source: UniProtKB
Protein phosphorylation Source: MGI
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Cellular Location
Secreted
PTM
Phosphorylated by FAM20C in the extracellular medium.

Xiao, Z., Xie, Y., Huang, F., Yang, J., Liu, X., Lin, X., ... & Zheng, S. (2022). MicroRNA-205-5p plays a suppressive role in the high-fat diet-induced atrial fibrosis through regulation of the EHMT2/IGFBP3 axis. Genes & Nutrition, 17(1), 1-17.

Yang, J., He, Q., Wang, Y., Pan, Z., Zhang, G., Liang, J., ... & Chen, P. (2022). Gegen Qinlian Decoction ameliorates type 2 diabetes osteoporosis via IGFBP3/MAPK/NFATc1 signaling pathway based on cytokine antibody array. Phytomedicine, 94, 153810.

Almalki, A., Thomas, J. T., Khan, A. R. A., Almulhim, B., Alassaf, A., Alghamdi, S. A., ... & Alotaibi, S. (2022). Correlation between Salivary Levels of IGF-1, IGFBP-3, IGF-1/IGFBP3 Ratio with Skeletal Maturity Using Hand-Wrist Radiographs. International Journal of Environmental Research and Public Health, 19(6), 3723.

D’Addio, F., Maestroni, A., Assi, E., Ben Nasr, M., Amabile, G., Usuelli, V., ... & Fiorina, P. (2022). The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Nature communications, 13(1), 684.

Jin, L., Shen, F., Weinfeld, M., & Sergi, C. (2020). Insulin growth factor binding protein 7 (IGFBP7)-related cancer and IGFBP3 and IGFBP7 crosstalk. Frontiers in Oncology, 10, 727.

Long, Z., Gong, F., Li, Y., Fan, Z., & Li, J. (2020). Circ_0000285 regulates proliferation, migration, invasion and apoptosis of osteosarcoma by miR-409-3p/IGFBP3 axis. Cancer cell international, 20, 1-11.

Li, C. L., Liu, B., Wang, Z. Y., Xie, F., Qiao, W., Cheng, J., ... & Liu, D. S. (2020). Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3. Journal of molecular and cellular cardiology, 139, 98-112.

Yin, L., Chen, J., Ma, C., Pei, S., Du, M., Zhang, Y., ... & Feng, J. (2020). Hsa_circ_0046263 functions as a ceRNA to promote nasopharyngeal carcinoma progression by upregulating IGFBP3. Cell Death & Disease, 11(7), 562.

Xiong, L. L., Xue, L. L., Du, R. L., Zhou, H. L., Tan, Y. X., Ma, Z., ... & Wang, T. H. (2020). Vi4-miR-185-5p-Igfbp3 network protects the brain from neonatal hypoxic ischemic injury via promoting neuron survival and suppressing the cell apoptosis. Frontiers in Cell and Developmental Biology, 8, 529544.

Chen, C. H., Chen, P. Y., Lin, Y. Y., Feng, L. Y., Chen, S. H., Chen, C. Y., ... & Wei, K. C. (2019). Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. Journal of Neurosurgery, 132(1), 168-179.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IGFBP3 Recombinant Antibody (2G6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare