IGHA2

IGHA2 (Immunoglobulin Heavy Constant Alpha 2 (A2m Marker)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGHA1.
Full Name
Immunoglobulin heavy constant alpha 2
Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Biological Process
Antibacterial humoral response Source: UniProtKB
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Glomerular filtration Source: UniProtKB
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Positive regulation of respiratory burst Source: UniProtKB
Retina homeostasis Source: UniProtKB
Cellular Location
Secreted; Cell membrane
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Anti-IGHA2 antibodies

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Mouse Anti-IGHA2 Recombinant Antibody (CBYY-I1615) (CBMAB-I2785-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1615
Application*: E, WB, P
Datasheet SDS

Rabbit Anti-IGHA2 Recombinant Antibody (RM125) (CBMAB-BR282LY)

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Target: IGHA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM125
Application*: ELISA, IHC
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (CBYY-I1864) (CBMAB-I3034-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Monkey
Clone: CBYY-I1864
Application*: E
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (CBYY-I1576) (CBMAB-I2746-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1576
Application*: WB, SE
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (AS2) (CBMAB-I1914-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AS2
Application*: WB
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (CBYY-I0831) (CBMAB-I1877-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0831
Application*: E, IH, P
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (CBYY-I0830) (CBMAB-I1869-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0830
Application*: E
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (A9604D2) (CBMAB-I1868-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A9604D2
Application*: WB, E, C
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (CBYY-I0829) (CBMAB-I1867-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0829
Application*: WB, SE
Datasheet SDS

Mouse Anti-IGHA2 Recombinant Antibody (14AS) (CBMAB-I0184-YY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14AS
Application*: E
Datasheet SDS

Mouse Anti-IGHA2 Monoclonal Antibody (CBFYH-3275) (CBMAB-H3602-FY)

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Target: IGHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3275
Application*: E, C, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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