IL1B Antibodies

Structure of IL1B

IL1B is a cytokine precursor protein with a molecular weight of approximately 17.5 kDa, which varies slightly among different species due to differences in amino acid sequences.

This protein is composed of 269 amino acids, and its spatial structure is mainly based on β -cloverleaf folding. IL1B does not contain a cofactor, and its activity depends on the formation of a homodimer. The protein surface has specific receptor-binding rings, composed of the 4th, 5th, and 6th β folding and junction ring regions, which are crucial for triggering downstream inflammatory signals. Its active center is maintained in stability and biological activity by residues such as Glu105 and Lys103.

Fig. 1 Schematic representation of IL-1β genes.¹

Key structural properties of IL1B:

• Clover-like spatial structures consisting mainly of β-folds
• Hydrophobic core protein is responsible for maintaining stability and receptor interface
• Contains no prosthetic group, ring structure and through specific surface IL1 receptor
• Key amino acid residues (such as Glu105, Lys103) are involved in dimerization and signal activation

Functions of IL1B

The main function of the protein encoded by the IL1B gene is to mediate inflammatory responses and immune regulation, and it is also involved in various pathophysiological processes such as apoptosis, fever response and tissue repair.

The activity of IL1B is strictly regulated at multiple levels through transcription and post-translation. Its maturation and release require caspase-1-mediated cleavage, a characteristic that distinguishes it from most directly secreted cytokines, highlighting its core position in both acute and chronic inflammation.

Applications of IL1B and IL1B Antibody in Literature

1. Chen, Jie, et al. "IL1B polymorphism is associated with essential tremor in Chinese population." BMC neurology 19.1 (2019): 99. https://doi.org/10.1186/s12883-019-1331-5

This study has for the first time discovered that the rs1143633 polymorphism of the IL1B gene is significantly associated with the risk of essential tremor in the Chinese population (OR=2.57). This variation may be involved in the occurrence of the disease by influencing gene expression in brain tissue, but its causal relationship needs to be further verified.

2. Peng, Shixiong, et al. "Integrated bioinformatics and validation reveal IL1B and its related molecules as potential biomarkers in chronic spontaneous urticaria." Frontiers in Immunology 13 (2022): 850993. https://doi.org/10.3389/fimmu.2022.850993

Research has found that the IL1B gene is a key biomarker for chronic spontaneous urticaria (CSU). Its upregulation is significantly associated with the infiltration of live fertilizer cells and participates in inflammation through the NOD-like receptor pathway, which is expected to become a potential therapeutic target.

3. Chen, Junjie, et al. "Analysis of prognostic biomarker models of TXNIP/NLRP3/IL1B inflammasome pathway in patients with acute myeloid leukemia." International Journal of Medical Sciences 21.8 (2024): 1438. https://www.medsci.org/v21p1438.htm

Research has found that IL1B is significantly upregulated in acute myeloid leukemia (AML), and its high expression is closely related to the poor prognosis of patients. It can serve as a novel potential biomarker and therapeutic target for predicting the survival period of AML.

4. Piloto, Ana Margarida, et al. "Plastic antibodies tailored on quantum dots for an optical detection of myoglobin down to the femtomolar range." Scientific reports 8.1 (2018): 4944. https://doi.org/10.1038/s41598-023-34069-z

Research has found that IL1B gene polymorphisms (such as rs1143633 and rs3136558) are associated with the risk of lung cancer in the population of Northeast China. Among them, specific haplotypes can increase the risk and interact with genes such as smoking duration and POLR1G.

5. Maculewicz, Ewelina, et al. "The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters." BMC genomics 23.1 (2022): 112. https://doi.org/10.1186/s12864-021-08258-x

Research has found that the IL1B gene polymorphism interacts with IL1RN, and this interaction is significantly correlated with body mass index (BMI) and body fat percentage. Its rare T allele may have a protective effect.

Creative Biolabs: IL1B Antibodies for Research

Creative Biolabs specializes in the production of high-quality IL1B antibodies for research and industrial applications. Our portfolio includes monoclonal antibodies tailored for ELISA, Flow Cytometry, Western blot, immunohistochemistry, and other diagnostic methodologies.

• Custom IL1B Antibody Development: Tailor-made solutions to meet specific research requirements.
• Bulk Production: Large-scale antibody manufacturing for industry partners.
• Technical Support: Expert consultation for protocol optimization and troubleshooting.
• Aliquoting Services: Conveniently sized aliquots for long-term storage and consistent experimental outcomes.

For more details on our IL1B antibodies, custom preparations, or technical support, contact us at email.