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Mouse Anti-IL1B Recombinant Antibody (A510) (CBMAB-AP3916LY)

The product is antibody recognizes IL1B. The antibody A510 immunoassay techniques such as: ICC, IHC, IP, WB.
See all IL1B antibodies

Summary

Host Animal
Mouse
Specificity
Pig
Clone
A510
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Val95~Met262
Specificity
Pig
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 1 Beta
Introduction
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Entrez Gene ID
397122
UniProt ID
P26889
Alternative Names
Interleukin 1 Beta
Function
MAA563Po26

Nguyen, H. D., Jo, W. H., Hoang, N. H. M., & Kim, M. S. (2022). Curcumin-attenuated TREM-1/DAP12/NLRP3/Caspase-1/IL1B, TLR4/NF-κB pathways, and tau hyperphosphorylation induced by 1, 2-diacetyl benzene: An in vitro and in silico study. Neurotoxicity Research, 40(5), 1272-1291.

Akhtari, M., Zargar, S. J., Vojdanian, M., Jamshidi, A., & Mahmoudi, M. (2021). Monocyte-derived and M1 macrophages from ankylosing spondylitis patients released higher TNF-α and expressed more IL1B in response to BzATP than macrophages from healthy subjects. Scientific Reports, 11(1), 17842.

Nakamizo, S., Dutertre, C. A., Khalilnezhad, A., Zhang, X. M., Lim, S., Lum, J., ... & Ginhoux, F. (2021). Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis. Journal of Experimental Medicine, 218(9), e20202345.

Gönen, M. S., Alaylıoğlu, M., Durcan, E., Özdemir, Y., Şahin, S., Konukoğlu, D., ... & Dursun, E. (2021). Rapid and effective vitamin D supplementation may present better clinical outcomes in COVID-19 (SARS-CoV-2) patients by altering serum INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Nutrients, 13(11), 4047.

Harati-Sadegh, M., Sargazi, S., Khorasani, M., Ansari-Moghaddam, A., Mirinejad, S., Sheervalilou, R., & Saravani, R. (2021). IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis. Ophthalmic Genetics, 42(5), 503-513.

Rawat, M., Nighot, M., Al-Sadi, R., Gupta, Y., Viszwapriya, D., Yochum, G., ... & Ma, T. Y. (2020). IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p, which degrades occludin mRNA. Gastroenterology, 159(4), 1375-1389.

Zhang, B., Chen, H., Ouyang, J., Xie, Y., Chen, L., Tan, Q., ... & Chen, L. (2020). SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect. Autophagy, 16(7), 1262-1278.

de Alencar, J. B., Zacarias, J. M. V., Tsuneto, P. Y., Souza, V. H. D., Silva, C. D. O. E., Visentainer, J. E. L., & Sell, A. M. (2020). Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility. PloS one, 15(1), e0227905.

Tulotta, C., Lefley, D. V., Freeman, K., Gregory, W. M., Hanby, A. M., Heath, P. R., ... & Ottewell, P. D. (2019). Endogenous production of IL1B by breast cancer cells drives metastasis and colonization of the bone microenvironment. Clinical Cancer Research, 25(9), 2769-2782.

Yi, G., Liang, M., Li, M., Fang, X., Liu, J., Lai, Y., ... & Liu, Z. (2018). A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. Inflammation Research, 67, 539-551.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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