INHA

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients.

inhibin subunit alpha

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:UniProtKB
Erythrocyte differentiation1 PublicationNAS:UniProtKB
Hemoglobin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Male gonad developmentIEA:Ensembl
Negative regulation of B cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell cycleManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of follicle-stimulating hormone secretion1 PublicationNAS:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of macrophage differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of phosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Ovarian follicle development1 PublicationNAS:UniProtKB
Positive regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell cycleManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:HGNC-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Secreted

Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.