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Mouse Anti-INHA Recombinant Antibody (CBYY-I1579) (CBMAB-I2749-YY)

This product is Mouse antibody that recognizes INHA. The antibody CBYY-I1579 can be used for immunoassay techniques such as: IHC-P, IHC-Fr
See all INHA antibodies

Summary

Host Animal
Mouse
Specificity
Dog, Human
Clone
CBYY-I1579
Antibody Isotype
IgG2a
Application
IHC-P, IHC-Fr

Basic Information

Specificity
Dog, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
inhibin subunit alpha
Introduction
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients.
Entrez Gene ID
Human3623
Dog488540
UniProt ID
HumanP05111
DogE2RIR3
Alternative Names
Inhibin Alpha Subunit
Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Biological Process
Cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:UniProtKB
Erythrocyte differentiation1 PublicationNAS:UniProtKB
Hemoglobin biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Male gonad developmentIEA:Ensembl
Negative regulation of B cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell cycleManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of follicle-stimulating hormone secretion1 PublicationNAS:UniProtKB
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of macrophage differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of phosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Ovarian follicle development1 PublicationNAS:UniProtKB
Positive regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell cycleManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:HGNC-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.

Weidemann, S., Noori, N. A., Lennartz, M., Reiswich, V., Dum, D., Menz, A., ... & Höflmayer, D. (2022). Inhibin Alpha expression in human tumors: a tissue microarray study on 12,212 tumors. Biomedicines, 10(10), 2507.

Cui, Z., Shen, X., Zhang, X., Li, F., Amevor, F. K., Zhu, Q., ... & Zhao, X. (2021). A functional polymorphism of inhibin alpha subunit at miR-181b-1-3p-binding site regulates proliferation and apoptosis of chicken ovarian granular cells. Cell and Tissue Research, 384, 545-560.

Putri, R. F., Nugraha, C. D., Furqon, A., Septian, W. A., & Suyadi, S. (2021). Identifikasi Keragaman Genetik Gen Inhibin Subunit Alpha (INHA) dan Inhibin Subunit Beta A (INHBA) Pada Sapi Peranakan Ongole (PO). TERNAK TROPIKA Journal of Tropical Animal Production, 22(1), 69-76.

Mete, O., Pakbaz, S., Lerario, A. M., Giordano, T. J., & Asa, S. L. (2021). Significance of alpha-inhibin expression in pheochromocytomas and paragangliomas. The American journal of surgical pathology, 45(9), 1264-1273.

Xu, K., Wang, J., Liu, H., Zhao, J., & Lu, W. (2020). Melatonin promotes the proliferation of chicken sertoli cells by activating the ERK/Inhibin alpha subunit signaling pathway. Molecules, 25(5), 1230.

Laird, M., Glister, C., Cheewasopit, W., Satchell, L. S., Bicknell, A. B., & Knight, P. G. (2019). ‘Free’inhibin α subunit is expressed by bovine ovarian theca cells and its knockdown suppresses androgen production. Scientific reports, 9(1), 19793.

Cui, Z., Liu, L., Zhao, X., Ran, J., Wang, Y., Yin, H., ... & Zhu, Q. (2019). Analysis of expression and single nucleotide polymorphisms of INHA gene associated with reproductive traits in chickens. BioMed Research International, 2019.

Yoon, W., Yoo, Y., Chae, Y. S., Kee, S. H., & Kim, B. M. (2018). Therapeutic advantage of genetically engineered Salmonella typhimurium carrying short hairpin RNA against inhibin alpha subunit in cancer treatment. Annals of Oncology, 29(9), 2010-2017.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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