KCNK3

Kcnk3 is a TWIK-related acid-sensitive K+ channel. It plays a role as an open rectifier baseline potassium channel.

Full Name

Potassium Two Pore Domain Channel Subfamily K Member 3

Function

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.

Biological Process

Brain developmentIEA:Ensembl
Cellular response to hypoxiaIEA:Ensembl
Cellular response to zinc ionIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Cochlea developmentIEA:Ensembl
Ion transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cytosolic calcium ion concentrationIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Response to xenobiotic stimulusIEA:Ensembl
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Pulmonary hypertension, primary, 4 (PPH4):
A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

Topology

Cytoplasmic: 1-8
Helical: 9-29
Pore-forming: 78-101
Helical: 108-128
Cytoplasmic: 129-158
Helical: 159-179
Pore-forming: 184-207
Helical: 223-243
Cytoplasmic: 244-394