Mouse Anti-KCNK3 Recombinant Antibody (S374-48) (CBMAB-K0057-LY)

Name: Mouse Anti-KCNK3 Recombinant Antibody (S374-48)
SKU: CBMAB-K0057-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

S374-48

Application

ICC, IHC, WB

Specificity

Rat

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% Glycerol

Preservative

0.1% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Potassium Two Pore Domain Channel Subfamily K Member 3

Introduction

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

Entrez Gene ID

29553

UniProt ID

O54912

Alternative Names

Task-1; rTASK

Function

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.

Biological Process

Brain developmentIEA:Ensembl
Cellular response to hypoxiaIEA:Ensembl
Cellular response to zinc ionIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Cochlea developmentIEA:Ensembl
Ion transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cytosolic calcium ion concentrationIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Response to xenobiotic stimulusIEA:Ensembl
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Pulmonary hypertension, primary, 4 (PPH4):
A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

Topology

Cytoplasmic: 1-8
Helical: 9-29
Pore-forming: 78-101
Helical: 108-128
Cytoplasmic: 129-158
Helical: 159-179
Pore-forming: 184-207
Helical: 223-243
Cytoplasmic: 244-394

Saint‐Martin Willer, A., Santos‐Gomes, J., Adão, R., Brás‐Silva, C., Eyries, M., Pérez‐Vizcaino, F., ... & Antigny, F. (2023). Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart. The Journal of Physiology, 601(17), 3717-3737.

Sörmann, J., Schewe, M., Proks, P., Jouen-Tachoire, T., Rao, S., Riel, E. B., ... & Tucker, S. J. (2022). Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea. Nature Genetics, 54(10), 1534-1543.

Lin, G., Lin, L., Lin, H., Chen, W., Chen, L., Chen, X., ... & Zeng, Y. (2022). KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway. Cell Death Discovery, 8(1), 360.

Lambert, M., Mendes-Ferreira, P., Ghigna, M. R., LeRibeuz, H., Adao, R., Boet, A., ... & Antigny, F. (2021). Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload. Cardiovascular Research, 117(12), 2474-2488.

West, J. D., Austin, E. D., Rizzi, E. M., Yan, L., Tanjore, H., Crabtree, A. L., ... & Rathinasabapathy, A. (2021). KCNK3 mutation causes altered immune function in pulmonary arterial hypertension patients and mouse models. International journal of molecular sciences, 22(9), 5014.

Le Ribeuz, H., Dumont, F., Ruellou, G., Lambert, M., Balliau, T., Quatredeniers, M., ... & Antigny, F. (2020). Proteomic analysis of KCNK3 loss of expression identified dysregulated pathways in pulmonary vascular cells. International Journal of Molecular Sciences, 21(19), 7400.

Le Ribeuz, H., Courboulin, A., Ghigna, M. R., Lambert, M., Hautefort, A., Humbert, M., ... & Antigny, F. (2020). In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression. Respiratory Research, 21(1), 1-14.

Lambert, M., Capuano, V., Boet, A., Tesson, L., Bertero, T., Nakhleh, M. K., ... & Antigny, F. (2019). Characterization of Kcnk3-mutated rat, a novel model of pulmonary hypertension. Circulation research, 125(7), 678-695.

Babicheva, A., Zhao, T., & Yuan, J. X. J. (2019). KCNK3 channel: a new player in the field of pulmonary vascular disease. Circulation Research, 125(7), 696-698.

Lambert, M., Boet, A., Rucker-Martin, C., Mendes-Ferreira, P., Capuano, V., Hatem, S., ... & Antigny, F. (2018). Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension. Cardiovascular research, 114(6), 880-893.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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