KIR2DL3
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3
Function
Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
Biological Process
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-265
Cytoplasmic: 266-341
Helical: 246-265
Cytoplasmic: 266-341
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Anti-KIR2DL3 antibodies
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CompareTarget: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: A764
Application*: Dot blot, ELISA, FC, WB
Target: KIR2DL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D8L3D
Application*: F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1906
Application*: F, IP
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 190IIC311
Application*: WB, F, E, IC/IF
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: P190IIC311AT
Application*: E, WB, IF, F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GL183
Application*: F, IP, WB
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CD158b
Application*: WB, F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4k10
Application*: E, F, WB
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1L34
Application*: F, N
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L670
Application*: F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 11G25
Application*: WB
Target: KIR2DL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-095
Application*: WB, F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-094
Application*: WB, IP, IF, E
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: KIR2DL3
Application*: F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14D21
Application*: IP
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3947
Application*: IP, WB, F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-2261
Application*: WB, F
Target: KIR2DL3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0718
Application*: F
Target: KIR2DL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2856
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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