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Mouse Anti-KIR2DL3 Recombinant Antibody (CBFYC-2856) (CBMAB-C2932-FY)

This product is mouse antibody that recognizes KIR2DL3. The antibody CBFYC-2856 can be used for immunoassay techniques such as: FC.
See all KIR2DL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2856
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Recombinant human KIR2DL3
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Entrez Gene ID
UniProt ID
Alternative Names
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3; P58 Natural Killer Cell Receptor Clone CL-6; CD158 Antigen-Like Family Member B2; Killer Inhibitory Receptor Cl 2-3; P58 NK Receptor CL-6; KIR-023GB; CD158B2; KIRCL23; NKAT2A; NKAT2B; NKAT-2; NKAT2; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3; Killer Cell Immunoglobulin-Like Receptor Two Domains Long Cytoplasmic Tail 3; Natural Killer Cell Inhibitory Receptor KIR2DL3
Function
Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
Biological Process
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-265
Cytoplasmic: 266-341
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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