loading...

KLF11

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.

Full Name

Kruppel like factor 11

Function

Transcription factor (PubMed:9748269, PubMed:10207080).
Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492).
Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity).
Induces apoptosis (By similarity).

Biological Process

Apoptotic processIEA:UniProtKB-KW
Cellular response to peptideIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Nucleus

Involvement in disease

Maturity-onset diabetes of the young 7 (MODY7):
A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

View more

Anti-KLF11 antibodies

+ Filters

Loading...

Rabbit Anti-KLF11 Recombinant Antibody (EG1800) (CBMAB-EN2148-LY)

Compare

Target: KLF11

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG1800

Application*: WB: 1:500~1:1000 ELISA: 1:20000

Mouse Anti-KLF11 Recombinant Antibody (CBXF-1008) (CBMAB-F1020-CQ)

Compare

Target: KLF11

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBXF-1008

Application*: WB, E, F

Mouse Anti-KLF11 Recombinant Antibody (KLF5J027) (CBMAB-K1065-LY)

Compare

Target: KLF11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: KLF5J027

Application*: DB, IC

Mouse Anti-KLF11 Recombinant Antibody (8F4) (CBMAB-K1064-LY)

Compare

Target: KLF11

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 8F4

Application*: E, IF, P, WB

Mouse Anti-KLF11 Recombinant Antibody (8C207) (CBMAB-K1063-LY)

Compare

Target: KLF11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 8C207

Application*: WB

Mouse Anti-KLF11 Recombinant Antibody (10D8) (CBMAB-K1062-LY)

Compare

Target: KLF11

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 10D8

Application*: IF, WB

Mouse Anti-KLF11 Recombinant Antibody (10C5) (CBMAB-K1061-LY)

Compare

Target: KLF11

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 10C5

Application*: E, WB

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry