KLF11

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
Full Name
Kruppel like factor 11
Function
Transcription factor (PubMed:9748269, PubMed:10207080).
Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492).
Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity).
Induces apoptosis (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cellular response to peptideIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
Maturity-onset diabetes of the young 7 (MODY7):
A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
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Anti-KLF11 antibodies

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Rabbit Anti-KLF11 Recombinant Antibody (EG1800) (CBMAB-EN2148-LY)

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Target: KLF11
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1800
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS

Mouse Anti-KLF11 Recombinant Antibody (CBXF-1008) (CBMAB-F1020-CQ)

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Target: KLF11
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBXF-1008
Application*: WB, E, F
Datasheet SDS

Mouse Anti-KLF11 Recombinant Antibody (KLF5J027) (CBMAB-K1065-LY)

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Target: KLF11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: KLF5J027
Application*: DB, IC
Datasheet SDS

Mouse Anti-KLF11 Recombinant Antibody (8F4) (CBMAB-K1064-LY)

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Target: KLF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8F4
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-KLF11 Recombinant Antibody (8C207) (CBMAB-K1063-LY)

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Target: KLF11
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 8C207
Application*: WB
Datasheet SDS

Mouse Anti-KLF11 Recombinant Antibody (10D8) (CBMAB-K1062-LY)

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Target: KLF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10D8
Application*: IF, WB
Datasheet SDS

Mouse Anti-KLF11 Recombinant Antibody (10C5) (CBMAB-K1061-LY)

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Target: KLF11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10C5
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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