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Mouse Anti-KLF11 Recombinant Antibody (10D8) (CBMAB-K1062-LY)

This product is antibody recognizes KLF11. The antibody 10D8 immunoassay techniques such as: IF, WB.
See all KLF11 antibodies
Published Data
Fig.1 Total protein was isolated from mouse cerebral vascular endothelial cells, and then a co-immunoprecipitation assay was performed for KLF11– PPAR interaction.
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Fig.2 The mRNA expression profile of 17 KLF family members and the protein level of KLF2, KLF4, KLF9, and KLF11 were detected by Western blotting.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
10D8
Antibody Isotype
IgG2a, κ
Application
IF, WB

Basic Information

Immunogen
KLF11 (NP_003588, 404 a.a. ~ 513 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kruppel like factor 11
Introduction
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Entrez Gene ID
8462
UniProt ID
O14901
Alternative Names
Kruppel Like Factor 11; Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 2; TGFB-Inducible Early Growth Response Protein 2; TIEG-2; TIEG2; FKLF;
Function
Transcription factor (PubMed:9748269, PubMed:10207080).
Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492).
Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity).
Induces apoptosis (By similarity).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cellular response to peptideIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
Maturity-onset diabetes of the young 7 (MODY7):
A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Grande, J., Jones, T. L., Sun, Z., Chanana, P., Jaiswal, I., Leontovich, A., ... & Khazaie, K. (2023). Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 166784.

Zhou, C., Sun, P., Hamblin, M. H., & Yin, K. J. (2022). Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury. Journal of Neuroinflammation, 19(1), 281.

De Lorenzo, S. B., Vrieze, A. M., Johnson, R. A., Lien, K. R., Nath, K. A., Garovic, V. D., ... & Grande, J. P. (2022). KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction. PloS one, 17(4), e0266454.

Bashir, M. I., Aziz, N. H. K. A., & Noor, D. A. M. (2022). Influence of Polygonum minus Aqueous Extract on Monoamine Oxidase-A Transcriptional Activators KLF-11 and SIRT1 Levels in the Hippocampus of Stress-induced Depressed Mice. International Journal of Pharmaceutical Investigation, 12(3).

Liang, W., Lu, H., Sun, J., Zhao, G., Wang, H., Guo, Y., ... & Zhang, J. (2021). KLF11 protects against venous thrombosis via suppressing tissue factor expression. Thrombosis and Haemostasis, 122(05), 777-788.

Lin, L., Mahner, S., Jeschke, U., & Hester, A. (2020). The distinct roles of transcriptional factor KLF11 in normal cell growth regulation and cancer as a mediator of TGF-β signaling pathway. International Journal of Molecular Sciences, 21(8), 2928.

Liang, W., Fan, Y., Lu, H., Chang, Z., Hu, W., Sun, J., ... & Chen, Y. E. (2019). KLF11 (Krüppel-like factor 11) inhibits arterial thrombosis via suppression of tissue factor in the vascular wall. Arteriosclerosis, thrombosis, and vascular biology, 39(3), 402-412.

Ji, Q., Li, Y., Zhao, Q., Fan, L. Q., Tan, B. B., Zhang, Z. D., ... & Jia, N. (2019). KLF11 promotes gastric cancer invasion and migration by increasing Twist1 expression. Neoplasma, 66(1), 92-100.

Hujie, G., Zhou, S. H., Zhang, H., Qu, J., Xiong, X. W., Hujie, O., ... & Yang, S. E. (2018). MicroRNA-10b regulates epithelial–mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma. Cancer cell international, 18, 1-9.

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For research use only. Not intended for any clinical use.

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