Mouse Anti-KLF11 Recombinant Antibody (8C207) (CBMAB-K1063-LY)

Name: Mouse Anti-KLF11 Recombinant Antibody (8C207)
SKU: CBMAB-K1063-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8C207

Application

Immunogen

Partial sequence of recombinant full-length protein to human KLF11

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Kruppel like factor 11

Introduction

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Entrez Gene ID

8462

UniProt ID

O14901

Alternative Names

Kruppel Like Factor 11; Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 2; TGFB-Inducible Early Growth Response Protein 2; TIEG-2; TIEG2; FKLF;

Function

Transcription factor (PubMed:9748269, PubMed:10207080).
Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492).
Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity).
Induces apoptosis (By similarity).

Biological Process

Apoptotic processIEA:UniProtKB-KW
Cellular response to peptideIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Nucleus

Involvement in disease

Maturity-onset diabetes of the young 7 (MODY7):
A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Grande, J., Jones, T. L., Sun, Z., Chanana, P., Jaiswal, I., Leontovich, A., ... & Khazaie, K. (2023). Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 166784.

Zhou, C., Sun, P., Hamblin, M. H., & Yin, K. J. (2022). Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury. Journal of Neuroinflammation, 19(1), 281.

De Lorenzo, S. B., Vrieze, A. M., Johnson, R. A., Lien, K. R., Nath, K. A., Garovic, V. D., ... & Grande, J. P. (2022). KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction. PloS one, 17(4), e0266454.

Bashir, M. I., Aziz, N. H. K. A., & Noor, D. A. M. (2022). Influence of Polygonum minus Aqueous Extract on Monoamine Oxidase-A Transcriptional Activators KLF-11 and SIRT1 Levels in the Hippocampus of Stress-induced Depressed Mice. International Journal of Pharmaceutical Investigation, 12(3).

Liang, W., Lu, H., Sun, J., Zhao, G., Wang, H., Guo, Y., ... & Zhang, J. (2021). KLF11 protects against venous thrombosis via suppressing tissue factor expression. Thrombosis and Haemostasis, 122(05), 777-788.

Lin, L., Mahner, S., Jeschke, U., & Hester, A. (2020). The distinct roles of transcriptional factor KLF11 in normal cell growth regulation and cancer as a mediator of TGF-β signaling pathway. International Journal of Molecular Sciences, 21(8), 2928.

Liang, W., Fan, Y., Lu, H., Chang, Z., Hu, W., Sun, J., ... & Chen, Y. E. (2019). KLF11 (Krüppel-like factor 11) inhibits arterial thrombosis via suppression of tissue factor in the vascular wall. Arteriosclerosis, thrombosis, and vascular biology, 39(3), 402-412.

Ji, Q., Li, Y., Zhao, Q., Fan, L. Q., Tan, B. B., Zhang, Z. D., ... & Jia, N. (2019). KLF11 promotes gastric cancer invasion and migration by increasing Twist1 expression. Neoplasma, 66(1), 92-100.

Hujie, G., Zhou, S. H., Zhang, H., Qu, J., Xiong, X. W., Hujie, O., ... & Yang, S. E. (2018). MicroRNA-10b regulates epithelial–mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma. Cancer cell international, 18, 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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