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KY

The protein encoded by this gene belongs to the transglutaminase-like superfamily. The protein is involved in the function, maturation and stabilization of the neuromuscular junction and may be required for normal muscle growth. Mutations in this gene are associated with myopathy, myofibrillar, 7. [provided by RefSeq, Apr 2017]

Full Name

Kyphoscoliosis Peptidase

Function

Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity).

Biological Process

Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line

Cellular Location

Myopathy, myofibrillar, 7 (MFM7):
A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM7 is an autosomal recessive form, clinically characterized by early childhood onset of slowly progressive muscle weakness and mild atrophy primarily affecting the lower limbs, associated with joint contractures.

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Anti-KY antibodies

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Mouse Anti-KY Recombinant Antibody (10B499) (CBMAB-K2085-LY)

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Target: KY

Host: Mouse

Antibody Isotype: IgM

Specificity: Sheep

Clone: 10B499

Application*: F, IH

Mouse Anti-KY Recombinant Antibody (76-7-4) (CBMAB-K0223-LY)

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Target: KY

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Pig

Clone: 76-7-4

Application*: F, C, IP

Mouse Anti-KY Recombinant Antibody (5K103) (CBMAB-K0222-LY)

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Target: KY

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Pig

Clone: 5K103

Application*: F, IH

Mouse Anti-KY Recombinant Antibody (10B498) (CBMAB-K0221-LY)

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Target: KY

Host: Mouse

Antibody Isotype: IgG1

Specificity: Sheep

Clone: 10B498

Application*: F, IH, IP

Mouse Anti-KY Recombinant Antibody (RIV12) (CBMAB-K2087-LY)

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Target: KY

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: RIV12

Application*: E, F, IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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