LAT

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

linker for activation of T cells

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Adaptive immune responseIEA:UniProtKB-KW
Calcium-mediated signalingManual Assertion Based On ExperimentIMP:HGNC-UCL
Gene expressionIEA:Ensembl
Immune responseManual Assertion Based On ExperimentIDA:HGNC-UCL
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:HGNC-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Lymphocyte homeostasisIEA:Ensembl
Mast cell degranulationIEA:UniProtKB-KW
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIEP:CACAO
Ras protein signal transductionManual Assertion Based On ExperimentIMP:HGNC-UCL
Regulation of T cell activationManual Assertion Based On ExperimentIMP:HGNC-UCL
T cell activationManual Assertion Based On ExperimentTAS:UniProtKB

Cell membrane
Present in lipid rafts.

Immunodeficiency 52 (IMD52):
An autosomal recessive primary immunodeficiency characterized by T-cell abnormalities, resulting in severe combined immunodeficiency, autoimmune disease, progressive lymphopenia and hypogammaglobulinemia, and lymphoproliferation with splenomegaly. Patients develop severe recurrent infections from infancy.

Extracellular: 1-4
Helical: 5-27
Cytoplasmic: 28-262

Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.
Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.