LEFTY2
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq]
Full Name
left-right determination factor 2
Function
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Left-right axis malformations (LRAM):
The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
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Anti-LEFTY2 antibodies
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CompareTarget: LEFTY2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1419
Application*: E, WB, P
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1417
Application*: E, P, WB
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1416
Application*: E
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCL-229
Application*: E, WB
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-228
Application*: E, WB, IH
Target: Lefty2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 836101
Application*: E, IC
Target: Lefty2
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2585
Application*: IC
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 7C5G1H6H10
Application*: E, WB
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1419
Application*: E, WB
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 5A25
Application*: WB
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1H6
Application*: E, WB
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1418
Application*: WB
Target: LEFTY2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-1416
Application*: WB
Target: LEFTY2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10G2
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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