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Rat Anti-Lefty2 Recombinant Antibody (CBYJL-2585) (CBMAB-L3022-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Left-Right Determination Factor 2 (Lefty2). The antibody can be used for immunoassay techniques, such as ICC.
See all Lefty2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJL-2585
Antibody Isotype
IgG
Application
ICC

Basic Information

Immunogen
Recombinant protein corresponding to mouse Lefty-2.
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
left-right determination factor 2
Introduction
Lefty2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which functions in left-right asymmetry determination of organ systems during development. Left-right determination factor 2 is also important in self-renewal and differentiation of mouse embryonic stem cells. Mice lacking a functional copy of this gene exhibit defects in axial and left-right patterning.
Entrez Gene ID
320202
UniProt ID
P57785
Alternative Names
Ebaf; Lefta; Leftb; lefty-2; lefty-B; 6030463A22Rik; left-right determination factor 2; endometrial bleeding associated factor; left-right determination factor B; left-right determination, factor A
Function
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Left-right axis malformations (LRAM):
The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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