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Mouse Anti-LEFTY2 Recombinant Antibody (CBYJT-1419) (CBMAB-T0442-YJ)

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Basic Information

Host Animal
Mouse
Clone
CBYJT-1419
Application
ELISA, WB, IHC-P
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
20 mM PBS, 150 mM NaCl, pH 7.2
Preservative
0.01% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
left-right determination factor 2
Introduction
LEFTY2 is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. LEFTY2 may also function in endometrial bleeding. Mutations in LEFTY2 have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of LEFTY2 in the endometrium. LEFTY2 is closely linked to both a related family member and a related pseudogene.
Entrez Gene ID
Human7044
Mouse320202
Rat289316
UniProt ID
HumanO00292
MouseP57785
RatQ5UCE3
Alternative Names
EBAF; LEFTA; TGFB4; LEFTYA
Function
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Left-right axis malformations (LRAM):
The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Ashiq, S., & Sabar, M. F. (2023). Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. Molecular Biology Reports, 1-8.

Yang, Y. R., Hu, S., Bu, F. T., Li, H., Huang, C., Meng, X. M., ... & Li, J. (2021). Circular RNA CREBBP suppresses hepatic fibrosis via targeting the hsa-miR-1291/LEFTY2 axis. Frontiers in pharmacology, 12, 741151.

Yang, Y. R., Bu, F. T., Yang, Y., Li, H., Huang, C., Meng, X. M., ... & Li, J. (2020). LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway. Molecular Immunology, 126, 31-39.

Zeng, N., Okumura, T., Alauddin, M., Khozooei, S., Rajaxavier, J., Zhang, S., ... & Salker, M. S. (2020). LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells. Plos one, 15(4), e0230044.

Alowayed, N. (2020). Die Wirkung von LEFTY 2 auf Zellmigration und Proliferation in Endometriumkarzinom (Doctoral dissertation, Universität Tübingen).

Gao, X., Cai, Y., & An, R. (2018). miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancer. International journal of molecular medicine, 42(3), 1229-1236.

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca 2+ entry

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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