Rabbit Anti-LEFTY2 Recombinant Antibody (
10G2) (V2LY-0725-LY994)

Name: Rabbit Anti-LEFTY2 Recombinant Antibody (10G2)
SKU: V2LY-0725-LY994
Rating: 5 (1 reviews)

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Tested Data

Rabbit Anti-LEFTY2 Recombinant Antibody (10G2) (V2LY-0725-LY994) in WB

Western Blot
Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate
All lanes: LEFTY2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 38 kDa
Observed band size: 36-45 kDa

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

10G2

Application

ELISA, WB

Immunogen

A synthesized peptide derived from human LEFTY2.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

left-right determination factor 2

Entrez Gene ID

7044

UniProt ID

O00292

Function

Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

Biological Process

BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

Involvement in disease

Left-right axis malformations (LRAM):
The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.

PTM

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Ashiq, S., & Sabar, M. F. (2023). Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. Molecular Biology Reports, 1-8.

Yang, Y. R., Hu, S., Bu, F. T., Li, H., Huang, C., Meng, X. M., ... & Li, J. (2021). Circular RNA CREBBP suppresses hepatic fibrosis via targeting the hsa-miR-1291/LEFTY2 axis. Frontiers in pharmacology, 12, 741151.

Yang, Y. R., Bu, F. T., Yang, Y., Li, H., Huang, C., Meng, X. M., ... & Li, J. (2020). LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway. Molecular Immunology, 126, 31-39.

Zeng, N., Okumura, T., Alauddin, M., Khozooei, S., Rajaxavier, J., Zhang, S., ... & Salker, M. S. (2020). LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells. Plos one, 15(4), e0230044.

Alowayed, N. (2020). Die Wirkung von LEFTY 2 auf Zellmigration und Proliferation in Endometriumkarzinom (Doctoral dissertation, Universität Tübingen).

Gao, X., Cai, Y., & An, R. (2018). miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancer. International journal of molecular medicine, 42(3), 1229-1236.

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca 2+ entry

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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