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Mouse Anti-LEFTY2 Recombinant Antibody (CBYCL-228) (CBMAB-L0129-YC)

Provided herein is a Mouse monoclonal antibody against Human LEFTY2. The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all LEFTY2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-228
Antibody Isotype
IgG
Application
ELISA, WB, IHC

Basic Information

Immunogen
Recognizes human LEFTY2. Species sequence homology: mouse and rat
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Liquid in 0.01% sodium azide, 150 mM sodium chloride
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
left-right determination factor 2
Introduction
LEFTY2 is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium.
Entrez Gene ID
7044
UniProt ID
O00292
Alternative Names
EBAF; TGFB4; LEFTA; LEFTYA
Function
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Left-right axis malformations (LRAM):
The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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