Human LEFTY2 ELISA Kit (V2LY-0626-LY4798)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0016 ng/mL
Detection Range
0.003-0.9 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
40.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
left-right determination factor 2
Function
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Left-right axis malformations (LRAM):
The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Ashiq, S., & Sabar, M. F. (2023). Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. Molecular Biology Reports, 1-8.

Yang, Y. R., Hu, S., Bu, F. T., Li, H., Huang, C., Meng, X. M., ... & Li, J. (2021). Circular RNA CREBBP suppresses hepatic fibrosis via targeting the hsa-miR-1291/LEFTY2 axis. Frontiers in pharmacology, 12, 741151.

Yang, Y. R., Bu, F. T., Yang, Y., Li, H., Huang, C., Meng, X. M., ... & Li, J. (2020). LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway. Molecular Immunology, 126, 31-39.

Zeng, N., Okumura, T., Alauddin, M., Khozooei, S., Rajaxavier, J., Zhang, S., ... & Salker, M. S. (2020). LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells. Plos one, 15(4), e0230044.

Alowayed, N. (2020). Die Wirkung von LEFTY 2 auf Zellmigration und Proliferation in Endometriumkarzinom (Doctoral dissertation, Universität Tübingen).

Gao, X., Cai, Y., & An, R. (2018). miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancer. International journal of molecular medicine, 42(3), 1229-1236.

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca 2+ entry

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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