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LHX4

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq]
Full Name
LHX4
Function
May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536).
Biological Process
Animal organ morphogenesisIEA:Ensembl
Medial motor column neuron differentiationIEA:Ensembl
Motor neuron axon guidanceIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Placenta developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Pituitary hormone deficiency, combined, 4 (CPHD4):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD4 is characterized by complete or partial deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone. Clinical features include short stature, cerebellar defects, and small sella turcica.
A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.

Anti-LHX4 antibodies

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Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1623) (CBMAB-L1480-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1623
Application*: E, WB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1624) (CBMAB-L1481-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1624
Application*: E, WB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1625) (CBMAB-L1482-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1625
Application*: WB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1626) (CBMAB-L1483-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-1626
Application*: WB, IP, IF, E

Mouse Anti-LHX4 Recombinant Antibody (LHX4E11E10) (CBMAB-L1484-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LHX4E11E10
Application*: DB

Mouse Anti-LHX4 Recombinant Antibody (CBYCL-298) (CBMAB-L0199-YC)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCL-298
Application*: E, P, WB

Mouse Anti-LHX4 Antibody (1B6) (CBMAB-0623-YC)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1B6
Application*: IP, M

Mouse Anti-LHX4 Antibody (1C11) (CBMAB-0624-YC)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C11
Application*: IP, M

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1621) (CBMAB-L1471-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1621
Application*: WB

Mouse Anti-LHX4 Recombinant Antibody (1D6) (CBMAB-L1472-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D6
Application*: E, IH, WB

Mouse Anti-LHX4 Recombinant Antibody (1H2) (CBMAB-L1473-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H2
Application*: E, WB

Mouse Anti-LHX4 Recombinant Antibody (2B12) (CBMAB-L1474-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B12
Application*: E, IF, WB

Mouse Anti-LHX4 Recombinant Antibody (2F3) (CBMAB-L1475-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F3
Application*: E

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1622) (CBMAB-L1476-YJ)

Datasheet SDS
Target: LHX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1622
Application*: E, IF, WB

LHX4 Matched Antibody Pair (690) (APMAB-690LY)

Datasheet SDS
Target: LHX4
Specificity: Human

LHX4 Matched Antibody Pair (691) (APMAB-691LY)

Datasheet SDS
Target: LHX4
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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