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LHX4

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq]

Full Name

LHX4

Function

May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536).

Biological Process

Animal organ morphogenesisIEA:Ensembl
Medial motor column neuron differentiationIEA:Ensembl
Motor neuron axon guidanceIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Placenta developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Pituitary hormone deficiency, combined, 4 (CPHD4):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD4 is characterized by complete or partial deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone. Clinical features include short stature, cerebellar defects, and small sella turcica.
A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.

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Anti-LHX4 antibodies

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LHX4 Matched Antibody Pair (691) (APMAB-691LY)

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Target: LHX4

Specificity: Human

LHX4 Matched Antibody Pair (690) (APMAB-690LY)

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Target: LHX4

Specificity: Human

Mouse Anti-LHX4 Recombinant Antibody (CBYCL-298) (CBMAB-L0199-YC)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYCL-298

Application*: E, P, WB

Mouse Anti-LHX4 Recombinant Antibody (LHX4E11E10) (CBMAB-L1484-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: LHX4E11E10

Application*: DB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1626) (CBMAB-L1483-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJL-1626

Application*: WB, IP, IF, E

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1625) (CBMAB-L1482-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1625

Application*: WB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1624) (CBMAB-L1481-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1624

Application*: E, WB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1623) (CBMAB-L1480-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-1623

Application*: E, WB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1622) (CBMAB-L1476-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-1622

Application*: E, IF, WB

Mouse Anti-LHX4 Recombinant Antibody (2F3) (CBMAB-L1475-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2F3

Application*: E

Mouse Anti-LHX4 Recombinant Antibody (2B12) (CBMAB-L1474-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B12

Application*: E, IF, WB

Mouse Anti-LHX4 Recombinant Antibody (1H2) (CBMAB-L1473-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1H2

Application*: E, WB

Mouse Anti-LHX4 Recombinant Antibody (1D6) (CBMAB-L1472-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D6

Application*: E, IH, WB

Mouse Anti-LHX4 Recombinant Antibody (CBYJL-1621) (CBMAB-L1471-YJ)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-1621

Application*: WB

Mouse Anti-LHX4 Antibody (1C11) (CBMAB-0624-YC)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C11

Application*: IP, M

Mouse Anti-LHX4 Antibody (1B6) (CBMAB-0623-YC)

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Target: LHX4

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 1B6

Application*: IP, M

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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