LIN9

LIN9 is a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. LIN9 also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Diseases associated with LIN9 include Algoneurodystrophy and Tuberculous Peritonitis. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition.

Full Name

lin-9 DREAM MuvB core complex component

Function

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.

Biological Process

Cell cycleIEA:UniProtKB-KW
DNA biosynthetic processIEA:UniProtKB-KW
Regulation of cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
ReproductionManual Assertion Based On ExperimentIBA:GO_Central
Transcription, DNA-templatedIEA:InterPro

Cellular Location

Nucleus, nucleoplasm
Found in perinucleolar structures. Associated with chromatin.