LYPD8

Lypd8 encodes a member of the Ly6/PLAUR family of cysteine-rich proteins that plays an important role in the protection of colonic epithelium from flagellated microbiota. LY6/PLAUR domain containing 8 undergoes proteolytic processing to generate a mature, glycosylphosphatidylinositol-anchored protein that is localized to the apical surface of the colonic epithelial cells. Mice lacking LY6/PLAUR domain containing 8 are sensitive to chemically induced intestinal inflammation.

Full Name

Ly6/Plaur Domain Containing 8

Function

Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.

Biological Process

Defense response to Gram-negative bacteriumISS:UniProtKB

Cellular Location

Cell membrane
Secreted
Secreted into the lumen of the colon following cleavage of the GPI-anchor.

PTM

Highly N-glycosylated. Not O-glycosylated.
GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen.