MAGI3

MAGI3 (Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3) is a Protein Coding gene. Diseases associated with MAGI3 include Lymphocytic Colitis. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include frizzled binding and guanylate kinase activity. An important paralog of this gene is MAGI2.

Full Name

MEMBRANE ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN CONTAINING 3

Function

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Biological Process

Apoptotic process1 PublicationNAS:UniProtKB
Intracellular signal transduction1 PublicationNAS:UniProtKB
Regulation of JNK cascadeIEA:InterPro
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cell junction, tight junction
Nucleus
Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity).

PTM

Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.