Mouse Anti-MAGI3 Recombinant Antibody (CBFYM-1341) (CBMAB-M1500-FY)

Name: Mouse Anti-MAGI3 Recombinant Antibody (CBFYM-1341)
SKU: CBMAB-M1500-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1341

Application

WB, ELISA, ICC

Specificity

Rat

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MEMBRANE ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN CONTAINING 3

Introduction

MAGI3 is a Protein Coding gene. Diseases associated with MAGI3 include Lymphocytic Colitis. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Ras signaling pathway. Gene Ontology annotations related to this gene include frizzled binding and guanylate kinase activity. An important paralog of this gene is MAGI2.

Entrez Gene ID

245903

UniProt ID

Q9JK71

Alternative Names

Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3; Membrane-Associated Guanylate Kinase Inverted 3; MAGI-3; Membrane-Associated Guanylate Kinase, WW And PDZ Domain-Containing Protein 3; Membrane-Associated Guanylate Kinase-Related 3; DJ730K3.2; KIAA1634

Function

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Biological Process

Apoptotic process1 PublicationNAS:UniProtKB
Intracellular signal transduction1 PublicationNAS:UniProtKB
Regulation of JNK cascadeIEA:InterPro
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cell junction, tight junction
Nucleus
Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity).

PTM

Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.

HE, J., Gu, S., Liu, H., Zhang, L., Lu, W., Zhao, C., ... & Feng, D. (2022). Low MAGI3 expression promotes Wnt/β-catenin signaling to mediate metastasis and rapalogs resistance of clear cell renal cell carcinoma.

Wang, H., Yang, W., Qin, Q., Yang, X., Yang, Y., Liu, H., ... & He, J. (2022). E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer. Molecular Cancer, 21(1), 1-19.

Xu, M., & Yu, T. (2022). MiR-20b-5p contributes to the dysfunction of vascular smooth muscle cells by targeting MAGI3 in hypertension. Journal of Molecular Histology, 53(2), 187-197.

Yang, Z., Liu, H., Song, R., Lu, W., Wang, H., Gu, S., ... & He, J. (2021). Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression. FEBS Open bio, 11(11), 3051-3062.

Zhang, Q., Ye, F., Guo, S., Xiao, W., Zhang, J., Qu, Y., & Zhang, J. (2021). Knockdown of lncRNA RMST protect against myocardial infarction through regulating miR-5692 and MAGI3 axis. American Journal of Translational Research, 13(4), 3906.

Weng, Q., Chen, M., Yang, W., Li, J., Fan, K., Xu, M., ... & Ji, J. (2020). Integrated analyses identify miR‐34c‐3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma. The FASEB Journal, 34(4), 5420-5434.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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