MMP15

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression.
Full Name
Matrix Metallopeptidase 15
Function
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
Biological Process
Cellular protein modification process Source: ProtInc
Collagen catabolic process Source: GO_Central
Endodermal cell differentiation Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ParkinsonsUK-UCL
Response to estradiol Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 132-625
Helical: 626-646
Cytoplasmic: 647-669
PTM
The precursor is cleaved by a furin endopeptidase.
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Anti-MMP15 antibodies

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Mouse Anti-MMP15 Recombinant Antibody (CBFYM-0047) (CBMAB-M0053-FY)

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Target: MMP15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0047
Application*: F
Datasheet SDS

Mouse Anti-MMP15 Recombinant Antibody (CBXS-0045) (CBMAB-S3046-CQ)

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Target: MMP15
Host: Mouse
Specificity: Human
Clone: CBXS-0045
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-MMP15 Recombinant Antibody (CBFYM-2370) (CBMAB-M2557-FY)

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Target: MMP15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2370
Application*: IH, WB
Datasheet SDS

Mouse Anti-MMP15 (AA 132-625) Recombinant Antibody (CBFYM-2369) (CBMAB-M2556-FY)

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Target: MMP15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2369
Application*: WB, IH, IP
Datasheet SDS

Mouse Anti-MMP15 Recombinant Antibody (CBFYM-0672) (CBMAB-M0808-FY)

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Target: MMP15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBFYM-0672
Application*: E, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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