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MMP15

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression.

Full Name

Matrix Metallopeptidase 15

Function

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Biological Process

Cellular protein modification process Source: ProtInc
Collagen catabolic process Source: GO_Central
Endodermal cell differentiation Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ParkinsonsUK-UCL
Response to estradiol Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 132-625
Helical: 626-646
Cytoplasmic: 647-669

PTM

The precursor is cleaved by a furin endopeptidase.

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Anti-MMP15 antibodies

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Mouse Anti-MMP15 Recombinant Antibody (CBFYM-0047) (CBMAB-M0053-FY)

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Target: MMP15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0047

Application*: F

Mouse Anti-MMP15 Recombinant Antibody (CBXS-0045) (CBMAB-S3046-CQ)

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Target: MMP15

Host: Mouse

Specificity: Human

Clone: CBXS-0045

Application*: WB, IC, P, C, E

Mouse Anti-MMP15 Recombinant Antibody (CBFYM-2370) (CBMAB-M2557-FY)

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Target: MMP15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2370

Application*: IH, WB

Mouse Anti-MMP15 (AA 132-625) Recombinant Antibody (CBFYM-2369) (CBMAB-M2556-FY)

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Target: MMP15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2369

Application*: WB, IH, IP

Mouse Anti-MMP15 Recombinant Antibody (CBFYM-0672) (CBMAB-M0808-FY)

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Target: MMP15

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBFYM-0672

Application*: E, IH, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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