MMP15

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression.

Matrix Metallopeptidase 15

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Cellular protein modification process Source: ProtInc
Collagen catabolic process Source: GO_Central
Endodermal cell differentiation Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ParkinsonsUK-UCL
Response to estradiol Source: Ensembl

Membrane

Extracellular: 132-625
Helical: 626-646
Cytoplasmic: 647-669

The precursor is cleaved by a furin endopeptidase.