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Mouse Anti-MMP15 (AA 132-625) Recombinant Antibody (CBFYM-2369) (CBMAB-M2556-FY)

This product is mouse antibody that recognizes MMP15. The antibody CBFYM-2369 can be used for immunoassay techniques such as: WB, IHC, IP.
See all MMP15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2369
Antibody Isotype
IgG1
Application
WB, IHC, IP

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human MMP-15, aa 132-625
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 132-625

Target

Full Name
Matrix Metallopeptidase 15
Introduction
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression.
Entrez Gene ID
UniProt ID
Alternative Names
Matrix Metallopeptidase 15; Matrix Metalloproteinase 15 (Membrane-Inserted); Matrix Metallopeptidase 15 (Membrane-Inserted); Membrane-Type Matrix Metalloproteinase 2; Membrane-Type-2 Matrix Metalloproteinase; MT-MMP 2; MT2-MMP; MMP-15
Function
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
Biological Process
Cellular protein modification process Source: ProtInc
Collagen catabolic process Source: GO_Central
Endodermal cell differentiation Source: UniProtKB
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Proteolysis Source: ParkinsonsUK-UCL
Response to estradiol Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 132-625
Helical: 626-646
Cytoplasmic: 647-669
PTM
The precursor is cleaved by a furin endopeptidase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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