MOV10

MOV10 (Mov10 RISC Complex RNA Helicase) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include helicase activity. An important paralog of this gene is MOV10L1.

Full Name

MOV10 RISC COMPLEX RNA HELICASE

Function

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324).

Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714).

In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849).

Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941).

Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351).

Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity).

May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324).

Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568).

(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Biological Process

3'-UTR-mediated mRNA destabilization Source: UniProtKB
Defense response to virus Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
miRNA-mediated gene silencing by mRNA destabilization Source: UniProtKB
Negative regulation of transposition, RNA-mediated Source: UniProtKB
Positive regulation of mRNA catabolic process Source: UniProtKB
Post-transcriptional gene silencing by RNA Source: GO_Central
Regulation of neuron projection arborization Source: UniProtKB

Cellular Location

Cytoplasm
Nucleus
Other locations
P-body
Cytoplasmic ribonucleoprotein granule
Stress granule
Note: Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568).