Sign in or Register   Sign in or Register
  |  

Mouse Anti-MOV10 (AA 953-1003) Recombinant Antibody (CBFYM-2481) (CBMAB-M2668-FY)

This product is mouse antibody that recognizes MOV10. The antibody CBFYM-2481 can be used for immunoassay techniques such as: IHC-P, IP, WB.
See all MOV10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2481
Antibody Isotype
IgG1, k
Application
IHC-P, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS
Preservative
0.09% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 953-1003

Target

Full Name
MOV10 RISC COMPLEX RNA HELICASE
Introduction
MOV10 is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology annotations related to this gene include helicase activity. An important paralog of this gene is MOV10L1.
Entrez Gene ID
4343
UniProt ID
Q9HCE1
Alternative Names
Mov10 RISC Complex RNA Helicase; Functional Spliceosome-Associated Protein 113; Moloney Leukemia Virus 10 Protein; Armitage Homolog; Mov10, Moloney Leukemia Virus 10, Homolog (Mouse); Mov10 (Moloney Leukemia Virus 10, Mouse) Homolog; Mov10, Moloney Leukemia Virus 10, Homolog
Function
5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324).

Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714).

In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849).

Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941).

Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351).

Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity).

May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324).

Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568).

(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
Biological Process
3'-UTR-mediated mRNA destabilization Source: UniProtKB
Defense response to virus Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
miRNA-mediated gene silencing by mRNA destabilization Source: UniProtKB
Negative regulation of transposition, RNA-mediated Source: UniProtKB
Positive regulation of mRNA catabolic process Source: UniProtKB
Post-transcriptional gene silencing by RNA Source: GO_Central
Regulation of neuron projection arborization Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
Other locations
P-body
Cytoplasmic ribonucleoprotein granule
Stress granule
Note: Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568).

Guan, Y., Gao, H., Leu, N. A., Vourekas, A., Alexiou, P., Maragkakis, M., ... & Wang, P. J. (2023). The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice. PLoS genetics, 19(5), e1010566.

Nawaz, A., Kenny, P. J., Shilikbay, T., Reed, M., Stuchlik, O., Pohl, J., & Ceman, S. (2023). Serine 970 of RNA helicase MOV10 is phosphorylated and controls unfolding activity and fate of mRNAs targeted for AGO2-mediated silencing. Journal of Biological Chemistry, 299(4).

Nawaz, A., Shilikbay, T., Skariah, G., & Ceman, S. (2022). Unwinding the roles of RNA helicase MOV10. Wiley Interdisciplinary Reviews: RNA, 13(2), e1682.

Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., & Li, H. (2022). Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences, 23(14), 7523.

Wang, L., Sola, I., Enjuanes, L., & Zuñiga, S. (2021). MOV10 helicase interacts with coronavirus nucleocapsid protein and has antiviral activity. MBio, 12(5), 10-1128.

Lidak, T., Baloghova, N., Korinek, V., Sedlacek, R., Balounova, J., Kasparek, P., & Cermak, L. (2021). CRL4-DCAF12 ubiquitin ligase controls MOV10 RNA helicase during spermatogenesis and T cell activation. International Journal of Molecular Sciences, 22(10), 5394.

Zhang, X., Yu, L., Ye, S., Xie, J., Huang, X., Zheng, K., & Sun, B. (2019). MOV10L1 binds RNA G-quadruplex in a structure-specific manner and resolves it more efficiently than MOV10. Iscience, 17, 36-48.

Liu, T., Sun, Q., Liu, Y., Cen, S., & Zhang, Q. (2019). The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription. Journal of Biological Chemistry, 294(51), 19804-19813.

Villalón-Letelier, F., & Reading, P. C. (2019). Unraveling the role of the MOV10 RNA helicase during influenza A virus infection. Biochemical Journal, 476(6), 1005-1008.

Fu, K., Tian, S., Tan, H., Wang, C., Wang, H., Wang, M., ... & Zheng, K. (2019). Biological and RNA regulatory function of MOV10 in mammalian germ cells. BMC biology, 17, 1-24.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MOV10 (AA 953-1003) Recombinant Antibody (CBFYM-2481)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare