NCK1

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

Full Name

NCK Adaptor Protein 1

Function

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

Biological Process

Actin filament organization Source: Ensembl
Cell migration Source: GO_Central
Ephrin receptor signaling pathway Source: Ensembl
Lamellipodium assembly Source: Ensembl
Negative regulation of cell death Source: UniProtKB
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of insulin receptor signaling pathway Source: FlyBase
Negative regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of PERK-mediated unfolded protein response Source: ParkinsonsUK-UCL
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Peptidyl-serine dephosphorylation Source: ParkinsonsUK-UCL
Positive regulation of actin filament polymerization Source: UniProtKB
Positive regulation of cap-dependent translational initiation Source: ParkinsonsUK-UCL
Positive regulation of cap-independent translational initiation Source: ParkinsonsUK-UCL
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of T cell proliferation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of translation in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Regulation of cell migration Source: Ensembl
Response to other organism Source: Ensembl
Signal complex assembly Source: UniProtKB
Signal transduction Source: GO_Central
Substrate-dependent cell migration, cell extension Source: Ensembl
T cell activation Source: UniProtKB

Cellular Location

Nucleus
Cytoplasm
Endoplasmic reticulum
Note: Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.

PTM

Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB.