Mouse Anti-NCK1 Recombinant Antibody (A1309) (CBMAB-AP5002LY)

NCK Adaptor Protein 1

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

NCK Adaptor Protein 1; SH2/SH3 Adaptor Protein NCK-Alpha; Nck-1; NCK; Non-Catalytic Region Of Tyrosine Kinase; Cytoplasmic Protein NCK1; Melanoma NCK Protein; NCK Tyrosine Kinase; NCKalpha;

01-A0222

Actin filament organization Source: Ensembl
Cell migration Source: GO_Central
Ephrin receptor signaling pathway Source: Ensembl
Lamellipodium assembly Source: Ensembl
Negative regulation of cell death Source: UniProtKB
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of insulin receptor signaling pathway Source: FlyBase
Negative regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Negative regulation of PERK-mediated unfolded protein response Source: ParkinsonsUK-UCL
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Peptidyl-serine dephosphorylation Source: ParkinsonsUK-UCL
Positive regulation of actin filament polymerization Source: UniProtKB
Positive regulation of cap-dependent translational initiation Source: ParkinsonsUK-UCL
Positive regulation of cap-independent translational initiation Source: ParkinsonsUK-UCL
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of T cell proliferation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of translation in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Regulation of cell migration Source: Ensembl
Response to other organism Source: Ensembl
Signal complex assembly Source: UniProtKB
Signal transduction Source: GO_Central
Substrate-dependent cell migration, cell extension Source: Ensembl
T cell activation Source: UniProtKB

Nucleus
Cytoplasm
Endoplasmic reticulum
Note: Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.

Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB.