NCOA3
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Full Name
Nuclear Receptor Coactivator 3
Function
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Biological Process
Cell dedifferentiation Source: UniProtKB
Cellular response to estradiol stimulus Source: BHF-UCL
Cellular response to hormone stimulus Source: GO_Central
Positive regulation of keratinocyte differentiation Source: UniProtKB
Positive regulation of stem cell population maintenance Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Receptor transactivation Source: UniProtKB
Regulation of stem cell division Source: UniProtKB
Cellular response to estradiol stimulus Source: BHF-UCL
Cellular response to hormone stimulus Source: GO_Central
Positive regulation of keratinocyte differentiation Source: UniProtKB
Positive regulation of stem cell population maintenance Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Receptor transactivation Source: UniProtKB
Regulation of stem cell division Source: UniProtKB
Cellular Location
Nucleus
Cytoplasm
Note: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
Cytoplasm
Note: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
PTM
Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
Methylated
Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
Methylated
Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
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Anti-NCOA3 antibodies
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CompareTarget: NCOA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: 5E11
Application*: WB, IP, CI, CI-seq
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11B1
Application*: WB, IF (IC), F
Target: NCOA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D1F11
Application*: WB, IP, IF (IC)
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3449
Application*: WB
Target: NCOA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1512
Application*: WB, P, F, IF
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0049
Application*: P, WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AX15.3
Application*: E, IH, P, IP, WB, CI
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: AX 15
Application*: IP, WB
Target: NCOA3
Host: Rabbit
Specificity: Human, Mouse, Monkey
Clone: CBXS-5347
Application*: WB, IP, IF
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-3650
Application*: F, IF, WB
Target: NCOA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-5751
Application*: WB, IP, CI
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D102
Application*: IP, WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4i291
Application*: WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 34/AIB-1
Application*: WB, IF
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B18
Application*: E, WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0783
Application*: IP, WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0782
Application*: IP
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0781
Application*: IP
Target: NCOA3
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: F-2
Application*: WB, IP, IF, E
Target: NCOA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1220
Application*: WB, P, IC, F
Target: NCOA3
Host: Mouse
Specificity: Human
Clone: E-11
Application*: WB, IP, IF, E
Target: NCOA3
Host: Mouse
Specificity: Human
Clone: B-3
Application*: WB, IP, IF, E
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H3
Application*: E, WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H9
Application*: WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C11B12
Application*: WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C1
Application*: WB, IP
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0128
Application*: E, WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AC3
Application*: WB, IH, IF, P
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0311
Application*: DB, WB
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1C10
Application*: IP, M
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B9
Application*: IP, M
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A11
Application*: IP, M
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT939
Application*: WB, E
Target: NCOA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4060
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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