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Mouse Anti-NCOA3 Antibody (1C10) (CBMAB-0710-YC)

Provided herein are mouse monoclonal antibodies against Human NCOA3. The antibody clone 1C10 can be used for immunoassay techniques, such as IP and MA.
See all NCOA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C10
Antibody Isotype
IgG2c
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Receptor Coactivator 3
Introduction
NCOA3 (nuclear receptor coactivator 3) is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. NCOA3 has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex.
Entrez Gene ID
8202
UniProt ID
Q9Y6Q9
Alternative Names
ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
Function
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Biological Process
Cell dedifferentiation Source: UniProtKB
Cellular response to estradiol stimulus Source: BHF-UCL
Cellular response to hormone stimulus Source: GO_Central
Positive regulation of keratinocyte differentiation Source: UniProtKB
Positive regulation of stem cell population maintenance Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Receptor transactivation Source: UniProtKB
Regulation of stem cell division Source: UniProtKB
Cellular Location
Nucleus
Cytoplasm
Note: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
PTM
Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
Methylated
Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.

Kiliti, A. J., Sharif, G. M., Martin, M. B., Wellstein, A., & Riegel, A. T. (2023). AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer. Frontiers in Endocrinology, 14, 1250218.

Li, X., Zhang, J., Wang, B., Chen, C., Zhang, E., Lv, Z., ... & Zhang, F. (2023). USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice. Biology Direct, 18(1), 37.

Liu, D., Li, J., Hao, W., Lin, X., Xia, J., Zhu, J., ... & Yang, X. (2022). Chimeric RNA TNNI2-ACTA1-V1 Regulates Cell Proliferation by Regulating the Expression of NCOA3. Frontiers in Veterinary Science, 9, 895190.

Li, Y., Liang, J., Dang, H., Zhang, R., Chen, P., & Shao, Y. (2022). NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways. Endocrine, 1-10.

Cui, Y., Fan, J., Shi, W., & Zhou, Z. (2022). Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR‐4458 in breast cancer. Drug Development Research, 83(1), 75-87.

de Semir, D., Bezrookove, V., Nosrati, M., Dar, A. A., Miller III, J. R., Leong, S. P., ... & Kashani-Sabet, M. (2021). Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation–Induced DNA Damage and Melanoma Susceptibility. Cancer research, 81(11), 2956-2969.

Zheng, X., Jia, Y., Qiu, L., Zeng, X., Xu, L., Wei, M., ... & Han, J. (2020). A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator. Journal of Biological Chemistry, 295(6), 1474-1488.

Li, W., Yan, Y., Zheng, Z., Zhu, Q., Long, Q., Sui, S., ... & Li, L. (2020). Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma. Cell death & disease, 11(11), 1011.

Qiao, J., Chen, Y., Mi, Y., Jin, H., Huang, T., Liu, L., ... & Zou, Z. (2020). NR5A2 synergizes with NCOA3 to induce breast cancer resistance to BET inhibitor by upregulating NRF2 to attenuate ferroptosis. Biochemical and Biophysical Research Communications, 530(2), 402-409.

Salazar-Silva, R., Dantas, V. L. G., Alves, L. U., Batissoco, A. C., Oiticica, J., Lawrence, E. A., ... & Mingroni-Netto, R. C. (2020). NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss. Human Molecular Genetics, 29(22), 3691-3705.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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