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NOS2

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.
Full Name
nitric oxide synthase 2
Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004, PubMed:7682706, PubMed:7504305).
In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity).
As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112).
Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Biological Process
Arginine catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Cell redox homeostasisTAS:Reactome
Cellular response to interferon-gammaIEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Cellular response to xenobiotic stimulusIEA:Ensembl
Circadian rhythmIEA:Ensembl
Defense response to bacteriumManual Assertion Based On ExperimentIMP:BHF-UCL
Defense response to Gram-negative bacterium1 PublicationNAS:BHF-UCL
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Innate immune response in mucosa1 PublicationNAS:BHF-UCL
Negative regulation of blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of gene expressionManual Assertion Based On ExperimentIGI:UniProtKB
Negative regulation of protein catabolic processIEA:Ensembl
Nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-cysteine S-nitrosylationISS:UniProtKB
Positive regulation of guanylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of killing of cells of another organismManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of leukocyte mediated cytotoxicityManual Assertion Based On ExperimentTAS:BHF-UCL
Prostaglandin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationIEA:Ensembl
Regulation of cellular respirationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of insulin secretionManual Assertion Based On ExperimentIMP:BHF-UCL
Response to bacterium1 PublicationNAS:UniProtKB
Response to hormoneManual Assertion Based On ExperimentIBA:GO_Central
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Superoxide metabolic processISS:UniProtKB
Cellular Location
Cytoplasm, cytosol
Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
PTM
Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.

Anti-NOS2 antibodies

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Target: NOS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: EPR16630
Application*: IP, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: NOS-IN
Application*: IC, IF, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: EPR16635
Application*: IC, IF, WB
Target: NOS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: D6B6S
Application*: WB, IP, IF (IC), F
Target: NOS2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse, Rat, Cattle
Clone: NOS-3F7-B11 B5
Application*: IC, IF, IH, C, IP, WB
Target: NOS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBYY-I1791
Application*: WB, IP, IF
Target: NOS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBYY-I1738
Application*: WB
Target: NOS2
Host: Rabbit
Specificity: Mouse
Clone: CBYY-I1679
Application*: WB, IP, IF, F
Target: NOS2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-I1246
Application*: E, IC, IF
Target: NOS2
Host: Mouse
Specificity: Human
Clone: CBYY-I1239
Application*: E, IC, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0748
Application*: E, IC, IF, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0746
Application*: E, IC, IF, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0623
Application*: WB, IF, IP
Target: NOS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP126
Application*: IH, P
Target: NOS2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0056
Application*: F, WB, WB, P, SE
Target: NOS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0055
Application*: WB, IF
Target: NOS2
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBWJN-0806
Application*: WB, IF
Target: NOS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0868
Application*: P
Target: NOS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: K13-A
Application*: E, C, P, IP, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJN-0482
Application*: E, IC, IF
Target: NOS2
Host: Mouse
Specificity: Human
Clone: CBWJN-0481
Application*: E, IC, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJN-0480
Application*: E, IC, IF, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 5C1B52
Application*: WB, IF
Target: NOS2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G4
Application*: E, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBWJN-0146
Application*: E
Target: NOS2
Host: Mouse
Antibody Isotype: IgM
Specificity: Cattle, Rat
Clone: CBWJN-0069
Application*: E, IC, WB
Target: NOS2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 4E5
Application*: F, E, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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