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Rabbit Anti-NOS2 Recombinant Antibody (CBYY-I1679) (CBMAB-I2849-YY)

This product is Rabbit antibody that recognizes NOS2. The antibody CBYY-I1679 can be used for immunoassay techniques such as: WB, IP, IF, FC
See all NOS2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBYY-I1679
Application
WB, IP, IF, FC

Basic Information

Specificity
Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nitric oxide synthase 2
Introduction
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.
Entrez Gene ID
UniProt ID
Alternative Names
Nitric Oxide Synthase 2; Nitric Oxide Synthase 2A (Inducible, Hepatocytes); Peptidyl-Cysteine S-Nitrosylase NOS2; Nitric Oxide Synthase 2, Inducible; Inducible NO Synthase; Hepatocyte NOS; Inducible NOS; EC 1.14.13.39; HEP-NOS;
Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004, PubMed:7682706, PubMed:7504305).
In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity).
As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112).
Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Biological Process
Arginine catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Cell redox homeostasisTAS:Reactome
Cellular response to interferon-gammaIEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Cellular response to xenobiotic stimulusIEA:Ensembl
Circadian rhythmIEA:Ensembl
Defense response to bacteriumManual Assertion Based On ExperimentIMP:BHF-UCL
Defense response to Gram-negative bacterium1 PublicationNAS:BHF-UCL
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Innate immune response in mucosa1 PublicationNAS:BHF-UCL
Negative regulation of blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of gene expressionManual Assertion Based On ExperimentIGI:UniProtKB
Negative regulation of protein catabolic processIEA:Ensembl
Nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-cysteine S-nitrosylationISS:UniProtKB
Positive regulation of guanylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of killing of cells of another organismManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of leukocyte mediated cytotoxicityManual Assertion Based On ExperimentTAS:BHF-UCL
Prostaglandin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationIEA:Ensembl
Regulation of cellular respirationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of insulin secretionManual Assertion Based On ExperimentIMP:BHF-UCL
Response to bacterium1 PublicationNAS:UniProtKB
Response to hormoneManual Assertion Based On ExperimentIBA:GO_Central
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Superoxide metabolic processISS:UniProtKB
Cellular Location
Cytoplasm, cytosol
Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
PTM
Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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