NPSR1

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Full Name

Neuropeptide S Receptor 1

Function

G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440).
Promotes mobilization of intracellular Ca2+ stores (PubMed:16790440).
Inhibits cell growth in response to NPS binding (PubMed:15947423).
Involved in pathogenesis of asthma and other IgE-mediated diseases.

Biological Process

Eating behaviorIEA:Ensembl
Negative regulation of defecationIEA:Ensembl
Negative regulation of eating behaviorIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of release of sequestered calcium ion into cytosolManual Assertion Based On ExperimentIDA:UniProtKB
Righting reflexIEA:Ensembl

Cellular Location

Isoform 1&3&4
Cell membrane
Isoform 2&5&6&7&9
Cytoplasm

Involvement in disease

Asthma-related traits 2 (ASRT2):
Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Topology

Extracellular: 1-52
Helical: 53-73
Cytoplasmic: 74-82
Helical: 83-103
Extracellular: 104-123
Helical: 124-144
Cytoplasmic: 145-164
Helical: 165-185
Extracellular: 186-212
Helical: 213-233
Cytoplasmic: 234-275
Helical: 276-296
Extracellular: 297-312
Helical: 313-333
Cytoplasmic: 334-371