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Mouse Anti-NPSR1 Recombinant Antibody (2F5) (CBMAB-A3540-LY)

The product is antibody recognizes GPR154. The antibody 2F5 immunoassay techniques such as: WB, ELISA.
See all NPSR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
GPR154 (NP_997056, 2 a.a. ~ 53 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Neuropeptide S Receptor 1
Introduction
This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Mutations in this gene have also been associated with this disease. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]
Entrez Gene ID
387129
UniProt ID
Q6W5P4
Alternative Names
ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1
Function
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440).
Promotes mobilization of intracellular Ca2+ stores (PubMed:16790440).
Inhibits cell growth in response to NPS binding (PubMed:15947423).
Involved in pathogenesis of asthma and other IgE-mediated diseases.
Biological Process
Eating behaviorIEA:Ensembl
Negative regulation of defecationIEA:Ensembl
Negative regulation of eating behaviorIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of release of sequestered calcium ion into cytosolManual Assertion Based On ExperimentIDA:UniProtKB
Righting reflexIEA:Ensembl
Cellular Location
Isoform 1&3&4
Cell membrane
Isoform 2&5&6&7&9
Cytoplasm
Involvement in disease
Asthma-related traits 2 (ASRT2):
Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Topology
Extracellular: 1-52
Helical: 53-73
Cytoplasmic: 74-82
Helical: 83-103
Extracellular: 104-123
Helical: 124-144
Cytoplasmic: 145-164
Helical: 165-185
Extracellular: 186-212
Helical: 213-233
Cytoplasmic: 234-275
Helical: 276-296
Extracellular: 297-312
Helical: 313-333
Cytoplasmic: 334-371

Ni, T., Guo, D., Tan, L., Xiao, Z., & Shi, Y. (2022). NPSR1-AS1 activates the MAPK pathway to facilitate thyroid cancer cell malignant behaviors via recruiting ELAVL1 to stabilize NPSR1 mRNA. Cell Cycle, 21(5), 439-449.

Peter, H. L., Giglberger, M., Frank, J., Streit, F., Zänkert, S., Kreuzpointner, L., ... & Wüst, S. (2022). The association between genetic variability in the NPS/NPSR1 system and chronic stress responses: A gene-environment-(quasi-) experiment. Psychoneuroendocrinology, 144, 105883.

Fang, C., Zhang, J., Wan, Y., Li, Z., Qi, F., Dang, Y., ... & Wang, Y. (2021). Neuropeptide S (NPS) and its receptor (NPSR1) in chickens: Cloning, tissue expression, and functional analysis. Poultry Science, 100(12), 101445.

Dastjerdi, S., Valizadeh, M., Nemati, R., Honardoost, M. A., Dolatabadi, N. F., Zamani, A., & Tabatabaeian, H. (2021). Highly expressed TLX1NB and NPSR1-AS1 lncRNAs could serve as diagnostic tools in colorectal cancer. Human Cell, 34(6), 1765-1774.

Hua, S., Gao, J., Li, T., Wang, M., You, L., Chen, G., ... & Liao, Q. (2021). The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1. Carcinogenesis, 42(3), 471-480.

He, H., Chen, T., Mo, H., Chen, S., Liu, Q., & Guo, C. (2020). Hypoxia-inducible long noncoding RNA NPSR1-AS1 promotes the proliferation and glycolysis of hepatocellular carcinoma cells by regulating the MAPK/ERK pathway. Biochemical and Biophysical Research Communications, 533(4), 886-892.

Schiele, M. A., Herzog, K., Kollert, L., Schartner, C., Leehr, E. J., Böhnlein, J., ... & Domschke, K. (2020). Extending the vulnerability–stress model of mental disorders: three-dimensional NPSR1× environment× coping interaction study in anxiety. The British Journal of Psychiatry, 217(5), 645-650.

Gechter, J., Liebscher, C., Geiger, M. J., Wittmann, A., Schlagenhauf, F., Lueken, U., ... & Ströhle, A. (2019). Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls. NeuroImage: Clinical, 24, 102029.

Gaertner, V. D., Michel, S., Curtin, J. A., Pulkkinen, V., Acevedo, N., Söderhäll, C., ... & Kabesch, M. (2019). Nocturnal asthma is affected by genetic interactions between RORA and NPSR1. Pediatric Pulmonology, 54(6), 847-857.

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For research use only. Not intended for any clinical use.

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