NRG2

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described. [provided by RefSeq]

Full Name

neuregulin 2

Function

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Biological Process

Animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Pro-neuregulin-2, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-2
Secreted

Topology

Extracellular: 112-405
Helical: 406-426
Cytoplasmic: 427-850

PTM

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.