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Mouse Anti-NRG2 Recombinant Antibody (A-12) (CBMAB-N3586-WJ)

This product is a Mouse antibody that recognizes NRG2. The antibody A-12 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NRG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A-12
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neuregulin 2
Introduction
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]
Entrez Gene ID
Human9542
Mouse100042150
Rat432361
UniProt ID
HumanO14511
MouseP56974
RatO35569
Alternative Names
Neuregulin 2; Neural- And Thymus-Derived Activator For ErbB Kinases; Divergent Of Neuregulin-1; Pro-NRG2; NTAK; Pro-Neuregulin-2, Membrane-Bound Isoform; DON1; HRG2;
Function
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Biological Process
Animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Pro-neuregulin-2, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-2
Secreted
Topology
Extracellular: 112-405
Helical: 406-426
Cytoplasmic: 427-850
PTM
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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