Mouse Nrg2 ELISA Kit (V2LY-0626-LY2750)

Name: Mouse Nrg2 ELISA Kit
SKU: V2LY-0626-LY2750
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0099 ng/mL

Detection Range

0.02-4.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Mouse

Assay Type

Sandwich

Reactivity

Mouse

Assay Time

1.5 h

Molecule Mass

82.2 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

neuregulin 2

Function

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Biological Process

Animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Pro-neuregulin-2, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-2
Secreted

Topology

Extracellular: 112-405
Helical: 406-426
Cytoplasmic: 427-850

PTM

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.

Nagasaka, M., & Ou, S. H. I. (2022). NRG1 and NRG2 fusion positive solid tumor malignancies: a paradigm of ligand-fusion oncogenesis. Trends in cancer, 8(3), 242-258.

Zhao, W. J., Yi, S. J., Ou, G. Y., & Qiao, X. Y. (2021). Neuregulin 2 (NRG2) is expressed in gliomas and promotes migration of human glioma cells. Folia Neuropathologica, 59(2), 189-197.

Zhao, W., & Lin, J. (2021). Neuregulin 2 is highly expressed in glioma tissues to regulate glial fibrillary acidic protein expression via Akt signaling. Nan fang yi ke da xue xue bao= Journal of Southern Medical University, 41(8), 1171-1176.

Czarnek, M., & Bereta, J. (2020). Proteolytic processing of neuregulin 2. Molecular neurobiology, 57(4), 1799-1813.

Shi, L., & Bergson, C. M. (2020). Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders. Translational Psychiatry, 10(1), 190.

Vullhorst, D., & Buonanno, A. (2019). NMDA receptors regulate neuregulin 2 binding to ER-PM junctions and ectodomain release. Molecular neurobiology, 56(12), 8345-8363.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NRG2 protein, His Tag (CAT#: V2LY-0526-LY5755)

Related Products

Human Recombinant NRG2 protein, His Tag (CAT#: V2LY-0526-LY5755)

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Mouse Anti-NRG2 Recombinant Antibody (CBYCD-566) (CAT#: CBMAB-D2147-YC)

Mouse Anti-NRG2 Recombinant Antibody (A-12) (CAT#: CBMAB-N3586-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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