Human Recombinant NRG2 protein, His Tag (V2LY-0526-LY5755)

Name: Human Recombinant NRG2 protein, His Tag
SKU: V2LY-0526-LY5755
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant NRG2 protein, His Tag consist of Amino Acid: 112-404 and predicts a molecular mass of 34 kDa.

Molecule Mass

34 kDa

Verified

HPLC

Sequence

Amino Acid: 112-404

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

neuregulin 2

Function

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Biological Process

Animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Pro-neuregulin-2, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-2
Secreted

Topology

Extracellular: 112-405
Helical: 406-426
Cytoplasmic: 427-850

PTM

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.By Similarity
Extensive glycosylation precedes the proteolytic cleavage.

Nagasaka, M., & Ou, S. H. I. (2022). NRG1 and NRG2 fusion positive solid tumor malignancies: a paradigm of ligand-fusion oncogenesis. Trends in cancer, 8(3), 242-258.

Zhao, W. J., Yi, S. J., Ou, G. Y., & Qiao, X. Y. (2021). Neuregulin 2 (NRG2) is expressed in gliomas and promotes migration of human glioma cells. Folia Neuropathologica, 59(2), 189-197.

Zhao, W., & Lin, J. (2021). Neuregulin 2 is highly expressed in glioma tissues to regulate glial fibrillary acidic protein expression via Akt signaling. Nan fang yi ke da xue xue bao= Journal of Southern Medical University, 41(8), 1171-1176.

Czarnek, M., & Bereta, J. (2020). Proteolytic processing of neuregulin 2. Molecular neurobiology, 57(4), 1799-1813.

Shi, L., & Bergson, C. M. (2020). Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders. Translational Psychiatry, 10(1), 190.

Vullhorst, D., & Buonanno, A. (2019). NMDA receptors regulate neuregulin 2 binding to ER-PM junctions and ectodomain release. Molecular neurobiology, 56(12), 8345-8363.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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