NTF4

This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
Full Name
Neurotrophin 4
Function
Target-derived survival factor for peripheral sensory sympathetic neurons.
Biological Process
Adult locomotory behaviorBy SimilarityISS:UniProtKB
Epidermis developmentBy SimilarityISS:UniProtKB
Ganglion mother cell fate determinationBy SimilarityISS:UniProtKB
InnervationIEA:Ensembl
Long-term memoryBy SimilarityISS:UniProtKB
Mechanoreceptor differentiationIEA:Ensembl
MemoryManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Nerve developmentManual Assertion Based On ExperimentIBA:GO_Central
Nerve growth factor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Neuron projection morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Peripheral nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Sensory organ boundary specificationBy SimilarityISS:UniProtKB
Taste bud developmentIEA:Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Glaucoma 1, open angle, O (GLC1O):
A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
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Anti-NTF4 antibodies

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Mouse Anti-NTF4 Recombinant Antibody (CBWJN-0684) (CBMAB-N3739-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0684
Application*: WB
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (PEPY051_hNT-4) (CBMAB-N3738-WJ)

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Target: NTF4
Host: Mouse
Specificity: Human
Clone: PEPY051_hNT-4
Application*: E
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (NYRhNT-4) (CBMAB-N3737-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NYRhNT-4
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (CBWJN-0679) (CBMAB-N3735-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0679
Application*: WB
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (CBWJN-0646) (CBMAB-N3734-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJN-0646
Application*: E, I, WB
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (CBWJN-0562) (CBMAB-N3732-WJ)

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Target: NTF4
Host: Mouse
Specificity: Human
Clone: CBWJN-0562
Application*: E
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (CBWJN-0484) (CBMAB-N3731-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-0484
Application*: E
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (31A1) (CBMAB-N3729-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 31A1
Application*: WB
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (1G12) (CBMAB-N3728-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G12
Application*: E, IC, IF
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (CBWJN-0238) (CBMAB-N3727-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0238
Application*: WB
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (2E8) (CBMAB-N3725-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E8
Application*: WB, IH, IF, P
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (CBWJN-1568) (CBMAB-N3724-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1568
Application*: WB, EC
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (CBWJN-1567) (CBMAB-N3723-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1567
Application*: WB
Datasheet SDS

Mouse Anti-NTF4 Recombinant Antibody (5C81) (CBMAB-N0549-WJ)

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Target: NTF4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5C81
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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