Mouse Anti-NTF4 Recombinant Antibody (2E8) (CBMAB-N3725-WJ)

Name: Mouse Anti-NTF4 Recombinant Antibody (2E8)
SKU: CBMAB-N3725-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E8

Application

WB, IHC, IF, IHC-P

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neurotrophin 4

Introduction

This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

Entrez Gene ID

4909

UniProt ID

P34130

Alternative Names

Neurotrophin 4; Neurotrophin 5 (Neurotrophin 4/5); Neurotrophic Factor 4; Neutrophic Factor 4; Neurotrophin-5; NTF5; NT-4; NT-5;

Function

Target-derived survival factor for peripheral sensory sympathetic neurons.

Biological Process

Adult locomotory behaviorBy SimilarityISS:UniProtKB
Epidermis developmentBy SimilarityISS:UniProtKB
Ganglion mother cell fate determinationBy SimilarityISS:UniProtKB
InnervationIEA:Ensembl
Long-term memoryBy SimilarityISS:UniProtKB
Mechanoreceptor differentiationIEA:Ensembl
MemoryManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Nerve developmentManual Assertion Based On ExperimentIBA:GO_Central
Nerve growth factor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Neuron projection morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Peripheral nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Sensory organ boundary specificationBy SimilarityISS:UniProtKB
Taste bud developmentIEA:Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

Involvement in disease

Glaucoma 1, open angle, O (GLC1O):
A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.

Sun, R., He, J., Xiang, Q., Feng, Y., Gong, Y., Ning, Y., ... & Xiang, T. (2023). NTF4 plays a dual role in breast cancer in mammary tumorigenesis and metastatic progression. International Journal of Biological Sciences, 19(2), 641.

Mu, L., Zhao, H., Zhang, Y., & Xiao, C. (2022). The Role of Neurotrophin-4/Forkhead Box L1 in the Development of Nonsmall-Cell Lung Cancer. Contrast Media & Molecular Imaging, 2022.

Omar, N. A., Kumar, J., & Teoh, S. L. (2022). Neurotrophin-3 and neurotrophin-4: The unsung heroes that lies behind the meninges. Neuropeptides, 92, 102226.

Yang, Z., Chen, Y., Wei, X., Wu, D., Min, Z., & Quan, Y. (2020). Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy. International Journal of Oncology, 56(6), 1442-1454.

Balim, D. Y., Ay, O. I., Ay, M. E., Karakas, U., Kenar, A. I., & Erdal, M. E. (2019). Are brain derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 gene expression changes effective in the pathogenesis of major depression?/Beyin kokenli norotrofik faktor, norotrofin-3 ve norotrofin-4 gen ekspresyon degisimleri major depresyonun patogenezinde etkili midir?. Anadolu Psikiyatri Dergisi, 20(6), 581-589.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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