OS9

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Full Name

OS9, Endoplasmic Reticulum Lectin

Function

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.

Biological Process

Endoplasmic reticulum unfolded protein responseIEA:InterPro
Negative regulation of retrograde protein transport, ER to cytosolManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Protein retention in ER lumenManual Assertion Based On ExperimentIDA:UniProtKB
Protein targetingIEA:Ensembl
Protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Response to endoplasmic reticulum stressManual Assertion Based On ExperimentIDA:UniProtKB
Retrograde protein transport, ER to cytosolManual Assertion Based On ExperimentIBA:GO_Central
Ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endoplasmic reticulum lumen

PTM

Intramolecular disulfide bonds.
Isoform 1 and isoform 2 are N-glycosylated.