P2RX5

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

purinergic receptor P2X, ligand-gated ion channel, 5

Receptor for ATP that acts as a ligand-gated ion channel.

Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of calcium ion transport into cytosol1 PublicationNAS:BHF-UCL
Positive regulation of calcium-mediated signaling1 PublicationNAS:BHF-UCL
Response to ATPIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Membrane

Cytoplasmic: 1-30
Helical: 31-51
Extracellular: 52-319
Helical: 320-340
Cytoplasmic: 341-422