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P2RX5

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

Full Name

purinergic receptor P2X, ligand-gated ion channel, 5

Function

Receptor for ATP that acts as a ligand-gated ion channel.

Biological Process

Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of calcium ion transport into cytosol1 PublicationNAS:BHF-UCL
Positive regulation of calcium-mediated signaling1 PublicationNAS:BHF-UCL
Response to ATPIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane

Topology

Cytoplasmic: 1-30
Helical: 31-51
Extracellular: 52-319
Helical: 320-340
Cytoplasmic: 341-422

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Anti-P2RX5 antibodies

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Mouse Anti-P2RX5 Recombinant Antibody (1C5) (CBMAB-P0585-YC)

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Target: P2RX5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C5

Application*: E, RNAi, WB

Mouse Anti-P2RX5 Recombinant Antibody (A-11) (CBMAB-P0587-YC)

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Target: P2RX5

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat

Clone: A-11

Application*: WB, IP, IF, E

Mouse Anti-P2RX5 Recombinant Antibody (2A2A6) (CBMAB-P0586-YC)

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Target: P2RX5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Pig, Rat

Clone: 2A2A6

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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